2j53

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{{Seed}}
 
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[[Image:2j53.png|left|200px]]
 
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==Solution Structure of GB1 domain Protein G and low and high pressure.==
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The line below this paragraph, containing "STRUCTURE_2j53", creates the "Structure Box" on the page.
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<StructureSection load='2j53' size='340' side='right'caption='[[2j53]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2j53]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_sp. Streptococcus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J53 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j53 OCA], [https://pdbe.org/2j53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j53 RCSB], [https://www.ebi.ac.uk/pdbsum/2j53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j53 ProSAT]</span></td></tr>
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{{STRUCTURE_2j53| PDB=2j53 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPG1_STRSG SPG1_STRSG] Binds to the constant Fc region of IgG with high affinity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j5/2j53_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j53 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of the GB1 domain of protein G at a pressure of 2 kbar is presented. The structure was calculated as a change from an energy-minimised low-pressure structure using (1)H chemical shifts. Two separate changes can be characterised: a compression/distortion, which is linear with pressure; and a stabilisation of an alternative folded state. On application of pressure, linear chemical shift changes reveal that the backbone structure changes by about 0.2 A root mean square, and is compressed by about 1% overall. The alpha-helix compresses, particularly at the C-terminal end, and moves toward the beta-sheet, while the beta-sheet is twisted, with the corners closest to the alpha-helix curling up towards it. The largest changes in structure are along the second beta-strand, which becomes more twisted. This strand is where the protein binds to IgG. Curved chemical shift changes with pressure indicate that high pressure also populates an alternative structure with a distortion towards the C-terminal end of the helix, which is likely to be caused by insertion of a water molecule. Proteins 2007. (c) 2007 Wiley-Liss, Inc.
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===SOLUTION STRUCTURE OF GB1 DOMAIN PROTEIN G AND LOW AND HIGH PRESSURE.===
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Pressure-induced changes in the solution structure of the GB1 domain of protein G.,Wilton DJ, Tunnicliffe RB, Kamatari YO, Akasaka K, Williamson MP Proteins. 2007 Dec 12;. PMID:18076052<ref>PMID:18076052</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18076052}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2j53" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18076052 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18076052}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2J53 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp. Streptococcus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J53 OCA].
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[[Category: Streptococcus sp]]
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[[Category: Akasaka K]]
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==Reference==
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[[Category: Kamatari YO]]
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Pressure-induced changes in the solution structure of the GB1 domain of protein G., Wilton DJ, Tunnicliffe RB, Kamatari YO, Akasaka K, Williamson MP, Proteins. 2007 Dec 12;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18076052 18076052]
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[[Category: Tunnicliffe RB]]
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[[Category: Single protein]]
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[[Category: Williamson MP]]
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[[Category: Streptococcus sp.]]
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[[Category: Wilton DJ]]
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[[Category: Akasaka, K.]]
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[[Category: Kamatari, Y O.]]
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[[Category: Tunnicliffe, R B.]]
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[[Category: Williamson, M P.]]
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[[Category: Wilton, D J.]]
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[[Category: Cell wall]]
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[[Category: Igg-binding protein]]
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[[Category: Immunoglobulin]]
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[[Category: Peptidoglycan-anchor]]
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[[Category: Pressure]]
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[[Category: Protein g]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:51:39 2008''
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Current revision

Solution Structure of GB1 domain Protein G and low and high pressure.

PDB ID 2j53

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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