2rp4

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{{Seed}}
 
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[[Image:2rp4.png|left|200px]]
 
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==Solution Structure of the oligomerization domain in Dmp53==
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The line below this paragraph, containing "STRUCTURE_2rp4", creates the "Structure Box" on the page.
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<StructureSection load='2rp4' size='340' side='right'caption='[[2rp4]]' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rp4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RP4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rp4 OCA], [https://pdbe.org/2rp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rp4 RCSB], [https://www.ebi.ac.uk/pdbsum/2rp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rp4 ProSAT]</span></td></tr>
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{{STRUCTURE_2rp4| PDB=2rp4 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8IH92_DROME Q8IH92_DROME]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The tetrameric state of p53, p63, and p73 has been considered one of the hallmarks of this protein family. While the DNA binding domain (DBD) is highly conserved among vertebrates and invertebrates, sequences C-terminal to the DBD are highly divergent. In particular, the oligomerization domain (OD) of the p53 forms of the model organisms Caenorhabditis elegans and Drosophila cannot be identified by sequence analysis. Here, we present the solution structures of their ODs and show that they both differ significantly from each other as well as from human p53. CEP-1 contains a composite domain of an OD and a sterile alpha motif (SAM) domain, and forms dimers instead of tetramers. The Dmp53 structure is characterized by an additional N-terminal beta-strand and a C-terminal helix. Truncation analysis in both domains reveals that the additional structural elements are necessary to stabilize the structure of the OD, suggesting a new function for the SAM domain. Furthermore, these structures show a potential path of evolution from an ancestral dimeric form over a tetrameric form, with additional stabilization elements, to the tetramerization domain of mammalian p53.
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===Solution Structure of the oligomerization domain in Dmp53===
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Structural evolution of C-terminal domains in the p53 family.,Ou HD, Lohr F, Vogel V, Mantele W, Dotsch V EMBO J. 2007 Jul 25;26(14):3463-73. Epub 2007 Jun 21. PMID:17581633<ref>PMID:17581633</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2rp4" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17581633 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17581633}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2RP4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP4 OCA].
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==Reference==
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Structural evolution of C-terminal domains in the p53 family., Ou HD, Lohr F, Vogel V, Mantele W, Dotsch V, EMBO J. 2007 Jul 25;26(14):3463-73. Epub 2007 Jun 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17581633 17581633]
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dmp53]]
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[[Category: Doetsch V]]
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[[Category: Nucleus]]
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[[Category: Ou HD]]
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[[Category: Oligomerization domain]]
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[[Category: P53]]
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[[Category: Tetramerizaiton domain]]
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[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:53:45 2008''
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Current revision

Solution Structure of the oligomerization domain in Dmp53

PDB ID 2rp4

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OCA

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