1n9u

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{{Seed}}
 
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[[Image:1n9u.png|left|200px]]
 
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==Differences and Similarities in Solution Structures of Angiotensin I & II: Implication for Structure-Function Relationship==
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The line below this paragraph, containing "STRUCTURE_1n9u", creates the "Structure Box" on the page.
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<StructureSection load='1n9u' size='340' side='right'caption='[[1n9u]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1n9u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N9U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n9u OCA], [https://pdbe.org/1n9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n9u RCSB], [https://www.ebi.ac.uk/pdbsum/1n9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n9u ProSAT]</span></td></tr>
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{{STRUCTURE_1n9u| PDB=1n9u | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ANGT_HUMAN ANGT_HUMAN] Genetic variations in AGT are a cause of susceptibility to essential hypertension (EHT) [MIM:[https://omim.org/entry/145500 145500]. Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause. Defects in AGT are a cause of renal tubular dysgenesis (RTD) [MIM:[https://omim.org/entry/267430 267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).<ref>PMID:16116425</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ANGT_HUMAN ANGT_HUMAN] Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.<ref>PMID:1132082</ref> <ref>PMID:10619573</ref> <ref>PMID:17138938</ref> Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.<ref>PMID:1132082</ref> <ref>PMID:10619573</ref> <ref>PMID:17138938</ref> Angiotensin-3: stimulates aldosterone release.<ref>PMID:1132082</ref> <ref>PMID:10619573</ref> <ref>PMID:17138938</ref> Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity).<ref>PMID:1132082</ref> <ref>PMID:10619573</ref> <ref>PMID:17138938</ref>
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===Differences and Similarities in Solution Structures of Angiotensin I & II: Implication for Strucure-Function Relationship===
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==See Also==
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*[[Angiotensin-Converting Enzyme|Angiotensin-Converting Enzyme]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12752436 is the PubMed ID number.
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</StructureSection>
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[[Category: Homo sapiens]]
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{{ABSTRACT_PUBMED_12752436}}
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[[Category: Large Structures]]
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[[Category: Cordopatis P]]
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==About this Structure==
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[[Category: Gerothanassis IP]]
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1N9U is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N9U OCA].
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[[Category: Magafa V]]
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[[Category: Manessi-Zoupa E]]
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==Reference==
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[[Category: Nikolakopoulou P]]
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Comparison of the solution structures of angiotensin I &amp; II. Implication for structure-function relationship., Spyroulias GA, Nikolakopoulou P, Tzakos A, Gerothanassis IP, Magafa V, Manessi-Zoupa E, Cordopatis P, Eur J Biochem. 2003 May;270(10):2163-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12752436 12752436]
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[[Category: Spyroulias GA]]
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[[Category: Single protein]]
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[[Category: Tzakos A]]
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[[Category: Cordopatis, P.]]
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[[Category: Gerothanassis, I P.]]
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[[Category: Magafa, V.]]
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[[Category: Manessi-Zoupa, E.]]
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[[Category: Nikolakopoulou, P.]]
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[[Category: Spyroulias, G A.]]
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[[Category: Tzakos, A.]]
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[[Category: Angiotensin]]
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[[Category: Nmr solution structure]]
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[[Category: Peptide]]
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[[Category: Renin-angiotensin system]]
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[[Category: Solid phase peptide synthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:55:04 2008''
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Current revision

Differences and Similarities in Solution Structures of Angiotensin I & II: Implication for Structure-Function Relationship

PDB ID 1n9u

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