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1pu3

From Proteopedia

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{{Seed}}
 
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[[Image:1pu3.png|left|200px]]
 
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==The Solution NMR Structure and Dynamics of a Recombinant Onconase with Altered N-terminal and Met23 residues==
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The line below this paragraph, containing "STRUCTURE_1pu3", creates the "Structure Box" on the page.
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<StructureSection load='1pu3' size='340' side='right'caption='[[1pu3]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pu3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lithobates_pipiens Lithobates pipiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PU3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pu3 OCA], [https://pdbe.org/1pu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pu3 RCSB], [https://www.ebi.ac.uk/pdbsum/1pu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pu3 ProSAT]</span></td></tr>
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{{STRUCTURE_1pu3| PDB=1pu3 | SCENE= }}
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</table>
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== Function ==
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===The Solution NMR Structure and Dynamics of a Recombinant Onconase with Altered N-terminal and Met23 residues===
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[https://www.uniprot.org/uniprot/RNP30_LITPI RNP30_LITPI] Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_14645226}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 14645226 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pu/1pu3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_14645226}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pu3 ConSurf].
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1PU3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rana_pipiens Rana pipiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PU3 OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Effect of N-terminal and Met23 mutations on the structure and dynamics of onconase., Gorbatyuk VY, Tsai CK, Chang CF, Huang TH, J Biol Chem. 2004 Feb 13;279(7):5772-80. Epub 2003 Nov 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14645226 14645226]
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[[Category: Large Structures]]
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[[Category: Rana pipiens]]
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[[Category: Lithobates pipiens]]
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[[Category: Single protein]]
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[[Category: Chang CF]]
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[[Category: Chang, C F.]]
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[[Category: Gorbatyuk VY]]
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[[Category: Gorbatyuk, V Y.]]
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[[Category: Huang TH]]
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[[Category: Huang, T H.]]
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[[Category: Tsai CK]]
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[[Category: Tsai, C K.]]
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[[Category: Bowl-shaped folding of the two sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:57:34 2008''
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Current revision

The Solution NMR Structure and Dynamics of a Recombinant Onconase with Altered N-terminal and Met23 residues

PDB ID 1pu3

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