2p9a

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{{Seed}}
 
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[[Image:2p9a.png|left|200px]]
 
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==E. coli methionine aminopeptidase dimetalated with inhibitor YE6==
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The line below this paragraph, containing "STRUCTURE_2p9a", creates the "Structure Box" on the page.
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<StructureSection load='2p9a' size='340' side='right'caption='[[2p9a]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2p9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P9A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=YE6:5-(2-CHLOROPHENYL)FURAN-2-CARBOHYDRAZIDE'>YE6</scene></td></tr>
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{{STRUCTURE_2p9a| PDB=2p9a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p9a OCA], [https://pdbe.org/2p9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p9a RCSB], [https://www.ebi.ac.uk/pdbsum/2p9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p9a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAP1_ECOLI MAP1_ECOLI] Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.[HAMAP-Rule:MF_01974]<ref>PMID:20521764</ref> <ref>PMID:3027045</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p9/2p9a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p9a ConSurf].
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<div style="clear:both"></div>
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===E. coli methionine aminopeptidase dimetalated with inhibitor YE6===
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==See Also==
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 17948983 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_17948983}}
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==About this Structure==
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2P9A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P9A OCA].
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==Reference==
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Inhibition of monometalated methionine aminopeptidase: inhibitor discovery and crystallographic analysis., Huang M, Xie SX, Ma ZQ, Huang QQ, Nan FJ, Ye QZ, J Med Chem. 2007 Nov 15;50(23):5735-42. Epub 2007 Oct 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17948983 17948983]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Methionyl aminopeptidase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Ye Q]]
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[[Category: Ye, Q.]]
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[[Category: Dimetalated]]
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[[Category: Dinuclear]]
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[[Category: Enzyme-inhibitor complex]]
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[[Category: Hydrolase]]
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[[Category: Metalloenzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:59:45 2008''
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Current revision

E. coli methionine aminopeptidase dimetalated with inhibitor YE6

PDB ID 2p9a

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