2ggz

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{{Seed}}
 
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[[Image:2ggz.png|left|200px]]
 
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==Crystal Structure of Human Guanylate Cyclase Activating Protein-3==
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The line below this paragraph, containing "STRUCTURE_2ggz", creates the "Structure Box" on the page.
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<StructureSection load='2ggz' size='340' side='right'caption='[[2ggz]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ggz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GGZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_2ggz| PDB=2ggz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ggz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggz OCA], [https://pdbe.org/2ggz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ggz RCSB], [https://www.ebi.ac.uk/pdbsum/2ggz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ggz ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of Human Guanylate Cyclase Activating Protein-3===
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== Function ==
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[https://www.uniprot.org/uniprot/GUC1C_HUMAN GUC1C_HUMAN] Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16626734}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16626734 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/2ggz_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16626734}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2GGZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGZ OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ggz ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies., Stephen R, Palczewski K, Sousa MC, J Mol Biol. 2006 Jun 2;359(2):266-75. Epub 2006 Apr 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16626734 16626734]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Stephen, R.]]
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[[Category: Stephen R]]
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[[Category: Ef hand]]
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[[Category: Gcap]]
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[[Category: Gcap-3]]
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[[Category: Gcap3]]
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[[Category: Guanylate cyclase activating protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:04:49 2008''
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Current revision

Crystal Structure of Human Guanylate Cyclase Activating Protein-3

PDB ID 2ggz

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