3b5d

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{{Seed}}
 
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[[Image:3b5d.png|left|200px]]
 
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==EmrE multidrug transporter in complex with TPP, C2 crystal form==
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The line below this paragraph, containing "STRUCTURE_3b5d", creates the "Structure Box" on the page.
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<StructureSection load='3b5d' size='340' side='right'caption='[[3b5d]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3b5d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B5D FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P4P:TETRAPHENYLPHOSPHONIUM'>P4P</scene></td></tr>
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{{STRUCTURE_3b5d| PDB=3b5d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b5d OCA], [https://pdbe.org/3b5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b5d RCSB], [https://www.ebi.ac.uk/pdbsum/3b5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b5d ProSAT]</span></td></tr>
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</table>
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===EmrE multidrug transporter in complex with TPP, C2 crystal form===
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== Function ==
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[https://www.uniprot.org/uniprot/EMRE_ECOLI EMRE_ECOLI] Multidrug transporter that expels positively charged hydrophobic drugs across the inner membrane of E.coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. Is involved in the resistance of E.coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP(+)) and benzalkonium.<ref>PMID:7896833</ref> <ref>PMID:10681497</ref> <ref>PMID:15371426</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18024586 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b5/3b5d_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18024586}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3B5D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B5D OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b5d ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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X-ray structure of EmrE supports dual topology model., Chen YJ, Pornillos O, Lieu S, Ma C, Chen AP, Chang G, Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18999-9004. Epub 2007 Nov, 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18024586 18024586]
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<references/>
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[[Category: Escherichia coli]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Chang, G.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Chen, Y J.]]
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[[Category: Large Structures]]
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[[Category: Antiport]]
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[[Category: Chang G]]
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[[Category: Helical membrane protein]]
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[[Category: Chen YJ]]
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[[Category: Inner membrane]]
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[[Category: Joint center for innovative membrane protein technology]]
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[[Category: Multidrug resistance transporter]]
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[[Category: Smr]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:08:54 2008''
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Current revision

EmrE multidrug transporter in complex with TPP, C2 crystal form

PDB ID 3b5d

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