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1pbw

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{{Seed}}
 
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[[Image:1pbw.png|left|200px]]
 
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==STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN==
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The line below this paragraph, containing "STRUCTURE_1pbw", creates the "Structure Box" on the page.
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<StructureSection load='1pbw' size='340' side='right'caption='[[1pbw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pbw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PBW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pbw OCA], [https://pdbe.org/1pbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pbw RCSB], [https://www.ebi.ac.uk/pdbsum/1pbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pbw ProSAT]</span></td></tr>
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{{STRUCTURE_1pbw| PDB=1pbw | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P85A_HUMAN P85A_HUMAN] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.<ref>PMID:7518429</ref> <ref>PMID:17626883</ref> <ref>PMID:19805105</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pb/1pbw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pbw ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN===
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==See Also==
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*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_8962058}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 8962058 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_8962058}}
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==About this Structure==
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1PBW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PBW OCA].
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==Reference==
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Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit., Musacchio A, Cantley LC, Harrison SC, Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14373-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8962058 8962058]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cantley, L C.]]
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[[Category: Cantley LC]]
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[[Category: Harrison, S C.]]
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[[Category: Harrison SC]]
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[[Category: Musacchio, A.]]
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[[Category: Musacchio A]]
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[[Category: Cdc42]]
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[[Category: Gap]]
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[[Category: Phosphoinositide 3-kinase]]
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[[Category: Phosphotransferase]]
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[[Category: Sh2 domain]]
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[[Category: Sh3 domain]]
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[[Category: Signal transduction]]
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[[Category: Tpase activating protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:09:23 2008''
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Current revision

STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN

PDB ID 1pbw

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