1oqj

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{{Seed}}
 
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[[Image:1oqj.png|left|200px]]
 
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==Crystal structure of the SAND domain from glucocorticoid modulatory element binding protein-1 (GMEB1)==
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The line below this paragraph, containing "STRUCTURE_1oqj", creates the "Structure Box" on the page.
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<StructureSection load='1oqj' size='340' side='right'caption='[[1oqj]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1oqj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OQJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1oqj| PDB=1oqj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqj OCA], [https://pdbe.org/1oqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oqj RCSB], [https://www.ebi.ac.uk/pdbsum/1oqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oqj ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the SAND domain from glucocorticoid modulatory element binding protein-1 (GMEB1)===
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== Function ==
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[https://www.uniprot.org/uniprot/GMEB1_HUMAN GMEB1_HUMAN] Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12702733}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12702733 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oq/1oqj_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12702733}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1OQJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQJ OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oqj ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions., Surdo PL, Bottomley MJ, Sattler M, Scheffzek K, Mol Endocrinol. 2003 Jul;17(7):1283-95. Epub 2003 Apr 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12702733 12702733]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bottomley, M J.]]
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[[Category: Bottomley MJ]]
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[[Category: Sattler, M.]]
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[[Category: Sattler M]]
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[[Category: Scheffzek, K.]]
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[[Category: Scheffzek K]]
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[[Category: Surdo, P L.]]
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[[Category: Surdo PL]]
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[[Category: Alpha-beta fold]]
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[[Category: Kdwk motif]]
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[[Category: Sand domain]]
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[[Category: Zinc-binding motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:23:44 2008''
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Current revision

Crystal structure of the SAND domain from glucocorticoid modulatory element binding protein-1 (GMEB1)

PDB ID 1oqj

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