1xyj

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{{Seed}}
 
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[[Image:1xyj.png|left|200px]]
 
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==NMR Structure of the cat prion protein==
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The line below this paragraph, containing "STRUCTURE_1xyj", creates the "Structure Box" on the page.
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<StructureSection load='1xyj' size='340' side='right'caption='[[1xyj]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xyj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Felis_catus Felis catus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XYJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyj OCA], [https://pdbe.org/1xyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xyj RCSB], [https://www.ebi.ac.uk/pdbsum/1xyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xyj ProSAT]</span></td></tr>
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{{STRUCTURE_1xyj| PDB=1xyj | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PRIO_FELCA PRIO_FELCA] Note=PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
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== Function ==
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[https://www.uniprot.org/uniprot/PRIO_FELCA PRIO_FELCA] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xy/1xyj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xyj ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The NMR structures of the recombinant cellular form of the prion proteins (PrPC) of the cat (Felis catus), dog (Canis familiaris), and pig (Sus scrofa), and of two polymorphic forms of the prion protein from sheep (Ovis aries) are presented. In all of these species, PrPC consists of an N-terminal flexibly extended tail with approximately 100 amino acid residues and a C-terminal globular domain of approximately 100 residues with three alpha-helices and a short antiparallel beta-sheet. Although this global architecture coincides with the previously reported murine, Syrian hamster, bovine, and human PrPC structures, there are local differences between the globular domains of the different species. Because the five newly determined PrPC structures originate from species with widely different transmissible spongiform encephalopathy records, the present data indicate previously uncharacterized possible correlations between local features in PrPC three-dimensional structures and susceptibility of different mammalian species to transmissible spongiform encephalopathies.
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===NMR Structure of the cat prion protein===
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Prion protein NMR structures of cats, dogs, pigs, and sheep.,Lysek DA, Schorn C, Nivon LG, Esteve-Moya V, Christen B, Calzolai L, von Schroetter C, Fiorito F, Herrmann T, Guntert P, Wuthrich K Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):640-5. Epub 2005 Jan 12. PMID:15647367<ref>PMID:15647367</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1xyj" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15647367}}, adds the Publication Abstract to the page
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*[[Prion 3D structures|Prion 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15647367 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15647367}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1XYJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Felis_catus Felis catus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYJ OCA].
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==Reference==
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Prion protein NMR structures of cats, dogs, pigs, and sheep., Lysek DA, Schorn C, Nivon LG, Esteve-Moya V, Christen B, Calzolai L, von Schroetter C, Fiorito F, Herrmann T, Guntert P, Wuthrich K, Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):640-5. Epub 2005 Jan 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15647367 15647367]
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[[Category: Felis catus]]
[[Category: Felis catus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Calzolai, L.]]
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[[Category: Calzolai L]]
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[[Category: Christen, B.]]
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[[Category: Christen B]]
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[[Category: Esteve-Moya, V.]]
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[[Category: Esteve-Moya V]]
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[[Category: Fiorito, F.]]
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[[Category: Fiorito F]]
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[[Category: Guntert, P.]]
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[[Category: Guntert P]]
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[[Category: Herrmann, T.]]
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[[Category: Herrmann T]]
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[[Category: Lysek, D A.]]
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[[Category: Lysek DA]]
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[[Category: Nivon, L G.]]
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[[Category: Nivon LG]]
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[[Category: Schorn, C.]]
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[[Category: Schorn C]]
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[[Category: Schroetter, C von.]]
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[[Category: Von Schroetter C]]
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[[Category: Nmr]]
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[[Category: Prion]]
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[[Category: Prnp]]
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[[Category: Prp]]
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[[Category: Tse]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:25:04 2008''
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Current revision

NMR Structure of the cat prion protein

PDB ID 1xyj

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