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1w37

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{{Seed}}
 
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[[Image:1w37.png|left|200px]]
 
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==2-keto-3-deoxygluconate(KDG) aldolase of Sulfolobus solfataricus==
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The line below this paragraph, containing "STRUCTURE_1w37", creates the "Structure Box" on the page.
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<StructureSection load='1w37' size='340' side='right'caption='[[1w37]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1w37]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W37 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_1w37| PDB=1w37 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w37 OCA], [https://pdbe.org/1w37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w37 RCSB], [https://www.ebi.ac.uk/pdbsum/1w37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w37 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KDGA_SACSO KDGA_SACSO] Involved in the degradation of glucose and galactose via the Entner-Doudoroff pathway. Catalyzes the reversible cleavage of 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxygluconate (KDG) forming pyruvate and glyceraldehyde 3-phosphate or glyceraldehyde, respectively. It is also able to catalyze the reversible cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) and 2-keto-3-deoxygalactonate (KDGal). It is equally active with both D- and L-glyceraldehyde.<ref>PMID:10527934</ref> <ref>PMID:12824170</ref> <ref>PMID:16330030</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/1w37_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w37 ConSurf].
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<div style="clear:both"></div>
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===2-KETO-3-DEOXYGLUCONATE(KDG) ALDOLASE OF SULFOLOBUS SOLFATARICUS===
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==See Also==
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*[[Aldolase 3D structures|Aldolase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15265860 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_15265860}}
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[[Category: Saccharolobus solfataricus]]
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[[Category: Connaris H]]
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==About this Structure==
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[[Category: Danson MJ]]
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1W37 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W37 OCA].
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[[Category: Hough DW]]
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[[Category: Lamble HJ]]
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==Reference==
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[[Category: Taylor GL]]
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The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus., Theodossis A, Walden H, Westwick EJ, Connaris H, Lamble HJ, Hough DW, Danson MJ, Taylor GL, J Biol Chem. 2004 Oct 15;279(42):43886-92. Epub 2004 Jul 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15265860 15265860]
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[[Category: Theodossis A]]
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[[Category: 2-dehydro-3-deoxyglucarate aldolase]]
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[[Category: Walden H]]
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[[Category: Single protein]]
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[[Category: Westwick EJ]]
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[[Category: Sulfolobus solfataricus]]
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[[Category: Connaris, H.]]
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[[Category: Danson, M J.]]
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[[Category: Hough, D W.]]
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[[Category: Lamble, H J.]]
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[[Category: Taylor, G L.]]
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[[Category: Theodossis, A.]]
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[[Category: Walden, H.]]
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[[Category: Westwick, E J.]]
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[[Category: Aldolase,archaeal metabolism,thermostability]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:30:34 2008''
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Current revision

2-keto-3-deoxygluconate(KDG) aldolase of Sulfolobus solfataricus

PDB ID 1w37

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