2p1m

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[[Image:2p1m.png|left|200px]]
 
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==TIR1-ASK1 complex structure==
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The line below this paragraph, containing "STRUCTURE_2p1m", creates the "Structure Box" on the page.
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<StructureSection load='2p1m' size='340' side='right'caption='[[2p1m]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2p1m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P1M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>
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{{STRUCTURE_2p1m| PDB=2p1m | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p1m OCA], [https://pdbe.org/2p1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p1m RCSB], [https://www.ebi.ac.uk/pdbsum/2p1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p1m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SKP1A_ARATH SKP1A_ARATH] Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends of the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1. SCF(UFO) is required for vegetative and floral organ development as well as for male gametogenesis. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1), SCF(ADO2), SCF(ADO3) are related to the circadian clock. SCF(ORE9) seems to be involved in senescence. SCF(EBF1/EBF2) may regulate ethylene signaling. Plays a role during embryogenesis and early postembryonic development, especially during cell elongation and division. Contributes to the correct chromosome segregation during tetrad formation.<ref>PMID:10528262</ref> <ref>PMID:10398681</ref> <ref>PMID:10500191</ref> <ref>PMID:11526079</ref> <ref>PMID:12970487</ref> <ref>PMID:14688296</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p1/2p1m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p1m ConSurf].
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<div style="clear:both"></div>
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===TIR1-ASK1 complex structure===
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==See Also==
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*[[Transport inhibitor response 1|Transport inhibitor response 1]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 17410169 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_17410169}}
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==About this Structure==
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2P1M is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P1M OCA].
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==Reference==
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Mechanism of auxin perception by the TIR1 ubiquitin ligase., Tan X, Calderon-Villalobos LI, Sharon M, Zheng C, Robinson CV, Estelle M, Zheng N, Nature. 2007 Apr 5;446(7136):640-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17410169 17410169]
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[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Calderon-Villalobos, L I.A.]]
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[[Category: Calderon-Villalobos LIA]]
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[[Category: Estelle, M.]]
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[[Category: Estelle M]]
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[[Category: Robinson, C V.]]
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[[Category: Robinson CV]]
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[[Category: Sharon, M.]]
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[[Category: Sharon M]]
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[[Category: Tan, X.]]
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[[Category: Tan X]]
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[[Category: Zheng, N.]]
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[[Category: Zheng N]]
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[[Category: F-box]]
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[[Category: Leucine rich repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:37:08 2008''
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Current revision

TIR1-ASK1 complex structure

PDB ID 2p1m

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