1qor

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1qor" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qor, resolution 2.2&Aring;" /> '''CRYSTAL STRUCTURE OF ...)
Current revision (08:15, 14 February 2024) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1qor.gif|left|200px]]<br /><applet load="1qor" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1qor, resolution 2.2&Aring;" />
 
-
'''CRYSTAL STRUCTURE OF ESCHERICHIA COLI QUINONE OXIDOREDUCTASE COMPLEXED WITH NADPH'''<br />
 
-
==Overview==
+
==CRYSTAL STRUCTURE OF ESCHERICHIA COLI QUINONE OXIDOREDUCTASE COMPLEXED WITH NADPH==
-
The crystal structure of the homodimer of quinone oxidoreductase from, Escherichia coli has been determined using the multiple isomorphous, replacement method at 2.2 A resolution and refined to an R-factor of 14.1%, The crystallographic asymmetric unit contains one functional dimer with, the two subunits being related by a non-crystallographic 2-fold symmetry, axis. The model consists of two polypeptide chains (residues 2 through, 327), one NADPH molecule and one sulphate anion per subunit, and 432 water, molecules. Each subunit consists of two domains: a catalytic domain and a, nucleotide-binding domain with the NADPH co-factor bound in the cleft, between domains. Quinone oxidoreductase has an unusual nucleotide-binding, fingerprint motif consisting of the sequence AXXGXXG. The overall, structure of quinone oxidoreductase shows strong structural homology to, that of horse liver alcohol dehydrogenase.
+
<StructureSection load='1qor' size='340' side='right'caption='[[1qor]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1qor]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QOR FirstGlance]. <br>
-
1QOR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with SO4 and NAP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QOR OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qor OCA], [https://pdbe.org/1qor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qor RCSB], [https://www.ebi.ac.uk/pdbsum/1qor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qor ProSAT]</span></td></tr>
-
Crystal structure of Escherichia coli QOR quinone oxidoreductase complexed with NADPH., Thorn JM, Barton JD, Dixon NE, Ollis DL, Edwards KJ, J Mol Biol. 1995 Jun 16;249(4):785-99. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7602590 7602590]
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/QOR1_ECOLI QOR1_ECOLI]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qo/1qor_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qor ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Barton, J.D.]]
+
[[Category: Barton JD]]
-
[[Category: Dixon, N.E.]]
+
[[Category: Dixon NE]]
-
[[Category: Edwards, K.J.]]
+
[[Category: Edwards KJ]]
-
[[Category: Ollis, D.L.]]
+
[[Category: Ollis DL]]
-
[[Category: Thorn, J.M.]]
+
[[Category: Thorn JM]]
-
[[Category: NAP]]
+
-
[[Category: SO4]]
+
-
[[Category: oxidoreductase]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 00:51:04 2007''
+

Current revision

CRYSTAL STRUCTURE OF ESCHERICHIA COLI QUINONE OXIDOREDUCTASE COMPLEXED WITH NADPH

PDB ID 1qor

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qor"
Personal tools