1qou

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(New page: 200px<br /><applet load="1qou" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qou, resolution 1.9&Aring;" /> '''CEN (CENTRORADIALIS) ...)
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[[Image:1qou.gif|left|200px]]<br /><applet load="1qou" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1qou, resolution 1.9&Aring;" />
 
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'''CEN (CENTRORADIALIS) PROTEIN FROM ANTIRRHINUM'''<br />
 
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==Overview==
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==CEN (Centroradialis) protein from Antirrhinum==
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Expression of the plant protein centroradialis (CEN) leads to a, morphological switch between shoot growth and the development of flower, structures (inflorescence). We have determined the crystal structure of, Antirrhinum CEN to 1.9 A resolution. This structure confirms the CEN, proteins as a subset of the family of phosphatidylethanolamine-binding, proteins (PEBP), as predicted from sequence homology. Mammalian forms of, PEBP have been found to act as inhibitors of MAP kinase signalling, a, central signalling cascade regulating cell differentiation. CEN and PEBP, proteins share a similar topology dominated by a large central beta-sheet., The strong conservation of a binding pocket at one end of this sheet which, is capable of binding phosphoryl ligands, suggests the biological effects, of CEN, like PEBP, arise from the ability of this region to form complexes, with phosphorylated ligands, hence interfering with kinases and their, effectors.
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<StructureSection load='1qou' size='340' side='right'caption='[[1qou]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qou]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Antirrhinum_majus Antirrhinum majus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QOU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qou OCA], [https://pdbe.org/1qou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qou RCSB], [https://www.ebi.ac.uk/pdbsum/1qou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qou ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CEN_ANTMA CEN_ANTMA] Expression of CEN leads to a morphological switch between shoot growth and the development of flower structures (inflorescence). May form complexes with phosphorylated ligands by interfering with kinases and their effectors.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qo/1qou_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qou ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Expression of the plant protein centroradialis (CEN) leads to a morphological switch between shoot growth and the development of flower structures (inflorescence). We have determined the crystal structure of Antirrhinum CEN to 1.9 A resolution. This structure confirms the CEN proteins as a subset of the family of phosphatidylethanolamine-binding proteins (PEBP), as predicted from sequence homology. Mammalian forms of PEBP have been found to act as inhibitors of MAP kinase signalling, a central signalling cascade regulating cell differentiation. CEN and PEBP proteins share a similar topology dominated by a large central beta-sheet. The strong conservation of a binding pocket at one end of this sheet which is capable of binding phosphoryl ligands, suggests the biological effects of CEN, like PEBP, arise from the ability of this region to form complexes with phosphorylated ligands, hence interfering with kinases and their effectors.
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==About this Structure==
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The structure of Antirrhinum centroradialis protein (CEN) suggests a role as a kinase regulator.,Banfield MJ, Brady RL J Mol Biol. 2000 Apr 14;297(5):1159-70. PMID:10764580<ref>PMID:10764580</ref>
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1QOU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Antirrhinum_majus Antirrhinum majus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QOU OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The structure of Antirrhinum centroradialis protein (CEN) suggests a role as a kinase regulator., Banfield MJ, Brady RL, J Mol Biol. 2000 Apr 14;297(5):1159-70. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10764580 10764580]
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</div>
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<div class="pdbe-citations 1qou" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Antirrhinum majus]]
[[Category: Antirrhinum majus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Banfield, M.J.]]
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[[Category: Banfield MJ]]
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[[Category: Brady, R.L.]]
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[[Category: Brady RL]]
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[[Category: influorescence determination in flowering plant meristem]]
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[[Category: member of the phosphatidylethanolamine binding protein family]]
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[[Category: signalling]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 00:51:08 2007''
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Current revision

CEN (Centroradialis) protein from Antirrhinum

PDB ID 1qou

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