1qow

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(New page: 200px<br /><applet load="1qow" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qow, resolution 1.06&Aring;" /> '''MERSACIDIN FROM BACI...)
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[[Image:1qow.jpg|left|200px]]<br /><applet load="1qow" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1qow, resolution 1.06&Aring;" />
 
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'''MERSACIDIN FROM BACILLUS'''<br />
 
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==Overview==
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==Mersacidin from Bacillus==
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The crystal structure of mersacidin, a potential novel antibiotic against, methicillin- and vancomycin-resistant Staphylococcus aureus strains, has, been determined by ab initio methods. Despite all crystals being, merohedrally twinned, an accurate structural model with an R value of, 13.4% has been obtained at atomic resolution. With six molecules in the, asymmetric unit and no atom heavier than sulfur, the structure corresponds, to a protein of 120 amino acids and is the largest approximately, equal-atom unknown structure solved by direct methods. In the crystal, the, molecule assumes a compact fold different from that found by NMR in, solution. Comparison of the NCS-related molecules reveals regions of, variable flexibility. The region highly homologous to the related, antibiotic actagardine is very rigid and possibly defines an essential, building block of this class of new antibacterial substances.
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<StructureSection load='1qow' size='340' side='right'caption='[[1qow]], [[Resolution|resolution]] 1.06&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1qow]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_sp._(in:_Bacteria) Bacillus sp. (in: Bacteria)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QOW FirstGlance]. <br>
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1QOW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_sp. Bacillus sp.] with MOH as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QOW OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.06&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=PRD_000199:Mersacidin'>PRD_000199</scene>, <scene name='pdbligand=TEE:2-AMINO-ETHENETHIOL'>TEE</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qow OCA], [https://pdbe.org/1qow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qow RCSB], [https://www.ebi.ac.uk/pdbsum/1qow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qow ProSAT]</span></td></tr>
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Ab initio structure determination of the lantibiotic mersacidin., Schneider TR, Karcher J, Pohl E, Lubini P, Sheldrick GM, Acta Crystallogr D Biol Crystallogr. 2000 Jun;56(Pt 6):705-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10818347 10818347]
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</table>
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[[Category: Bacillus sp.]]
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== Function ==
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[[Category: Single protein]]
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[https://www.uniprot.org/uniprot/MRSA_BACSY MRSA_BACSY] Kills a number of Gram-positive bacteria. Acts at the level of cell wall biosynthesis by interfering with bacterial peptidoglycan biosynthesis. Specifically inhibits the conversion of the lipid II intermediate into polymeric nascent glycan strands by transglycosylation. May interact with the peptidoglycan precursor rather than with the enzyme.
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[[Category: Kaercher, J.]]
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__TOC__
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[[Category: Schneider, T.R.]]
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</StructureSection>
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[[Category: Sheldrick, G.M.]]
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[[Category: Large Structures]]
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[[Category: MOH]]
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[[Category: Kaercher J]]
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[[Category: ab initio structure solution]]
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[[Category: Schneider TR]]
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[[Category: aba-s-cys]]
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[[Category: Sheldrick GM]]
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[[Category: beta-methyllanthionine]]
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[[Category: lantibiotics]]
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[[Category: merohedral twinning]]
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[[Category: methicillin resistance]]
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[[Category: staphylococcus aureus]]
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[[Category: thioether]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 00:51:17 2007''
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Current revision

Mersacidin from Bacillus

PDB ID 1qow

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