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1kjc

From Proteopedia

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'''Theoretical Model'''
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{{Theoretical_model}}
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The entry 1KJC is a Theoretical Model titled 'THEORETICAL MODEL OF THE HUMAN CD6 LIGAND ALCAM (ACTIVATED LEUKOCYTE-CELL ADHESION MOLECULE), N-TERMINAL RECEPTOR-BINDING DOMAIN'.
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==THEORETICAL MODEL OF THE HUMAN CD6 LIGAND ALCAM (ACTIVATED LEUKOCYTE-CELL ADHESION MOLECULE), N-TERMINAL RECEPTOR- BINDING DOMAIN==
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<StructureSection load='1kjc' size='340' side='right'caption='[[1kjc]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KJC FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kjc FirstGlance], [https://www.ebi.ac.uk/pdbsum/1kjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kjc ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CD6-ligand interactions have been implicated in the regulation of T-cell adhesion and activation. CD6 is a member of the scavenger receptor family, whereas its human ligand (ALCAM) belongs to the immunoglobulin superfamily. The extracellular region of ALCAM includes five immunoglobulin-like domains. As a fusion protein, the N-terminal extracellular domain of ALCAM (ALCAMD1) binds specifically to CD6. We report the construction, assessment, and analysis of a molecular model of ALCAMD1. The model defines the CDR-analogous loops, the location of N-linked glycosylation sites, and residues that form the beta-sheet faces of the immunoglobulin-like domain. Predicted structural characteristics of the A'GFCC'C" face of the model are consistent with the presence of monomeric and dimeric forms of ALCAMD1, which has implications for the receptor-ligand interactions.
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[[Category:Theoretical Model]]
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Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM.,Bajorath J, Bowen MA, Aruffo A Protein Sci. 1995 Aug;4(8):1644-7. PMID:8520490<ref>PMID:8520490</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 30 09:50:37 2008''
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</div>
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<div class="pdbe-citations 1kjc" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Theoretical Model]]
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[[Category: Large Structures]]
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[[Category: Aruffo, A]]
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[[Category: Bajorath, J]]
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[[Category: Bowen, M A]]

Current revision

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

THEORETICAL MODEL OF THE HUMAN CD6 LIGAND ALCAM (ACTIVATED LEUKOCYTE-CELL ADHESION MOLECULE), N-TERMINAL RECEPTOR- BINDING DOMAIN

PDB ID 1kjc

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