1qyj
From Proteopedia
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| - | + | {{Theoretical_model}} | |
| - | + | ==HISTOASPARTIC PROTEINASE FROM PLASMODIUM FALCIPARUM== | |
| + | <StructureSection load='1qyj' size='340' side='right'caption='[[1qyj]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QYJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qyj FirstGlance], [https://www.ebi.ac.uk/pdbsum/1qyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qyj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The primary structure of the so-called histoaspartic protease from Plasmodium falciparum has a very high percentage of identity and homology with the pepsin-like enzyme plasmepsin II. A homology modeling approach was used to calculate the three-dimensional structure of the enzyme. Molecular dynamics (MD) simulations were applied to find those structural properties of the histoaspartic protease that had a tendency to remain stable during all runs. The results have shown that hydrogen-bonded residues Ser37-His34-Asp214 are arranged without any strain, in a manner that resembles the active site of a serine protease, while Ser38 and Asn39 take up positions appropriate to formation of an oxyanion hole. Although there are several important differences between the enzyme and plasmepsin II, all of the structural features associated with a typical pepsin-like aspartic protease are present in the final model of the histoaspartic protease. A possibility that this enzyme may function as a serine protease is discussed. | ||
| - | + | Is histoaspartic protease a serine protease with a pepsin-like fold?,Andreeva N, Bogdanovich P, Kashparov I, Popov M, Stengach M Proteins. 2004 May 15;55(3):705-10. PMID:15103632<ref>PMID:15103632</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| + | <div class="pdbe-citations 1qyj" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Theoretical Model]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Andreeva, N S]] | ||
| + | [[Category: Bogdanovitch, P M]] | ||
| + | [[Category: Kashparov, I V]] | ||
| + | [[Category: Popov, M E]] | ||
| + | [[Category: Stengach, M A]] | ||
Current revision
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HISTOASPARTIC PROTEINASE FROM PLASMODIUM FALCIPARUM
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