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2vvt

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{{Seed}}
 
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[[Image:2vvt.png|left|200px]]
 
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<!--
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==Glutamate Racemase (MurI) from E. faecalis in complex with a 9-Benzyl Purine inhibitor==
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The line below this paragraph, containing "STRUCTURE_2vvt", creates the "Structure Box" on the page.
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<StructureSection load='2vvt' size='340' side='right'caption='[[2vvt]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vvt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VVT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=I24:2-BUTOXY-9-(2,6-DIFLUOROBENZYL)-N-(2-MORPHOLIN-4-YLETHYL)-9H-PURIN-6-AMINE'>I24</scene></td></tr>
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{{STRUCTURE_2vvt| PDB=2vvt | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vvt OCA], [https://pdbe.org/2vvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vvt RCSB], [https://www.ebi.ac.uk/pdbsum/2vvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vvt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MURI_ENTFA MURI_ENTFA] Provides the (R)-glutamate required for cell wall biosynthesis.[HAMAP-Rule:MF_00258]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vv/2vvt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vvt ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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An early SAR study of a screening hit series has generated a series of 9-benzyl purines as inhibitors of bacterial glutamate racemase (MurI) with micromolar enzyme potency and improved physical properties. X-ray co-crystal EI structures were obtained.
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===GLUTAMATE RACEMASE (MURI) FROM E. FAECALIS IN COMPLEX WITH A 9-BENZYL PURINE INHIBITOR===
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Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria.,Geng B, Breault G, Comita-Prevoir J, Petrichko R, Eyermann C, Lundqvist T, Doig P, Gorseth E, Noonan B Bioorg Med Chem Lett. 2008 Aug 1;18(15):4368-72. Epub 2008 Jun 24. PMID:18614367<ref>PMID:18614367</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2vvt" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18614367}}, adds the Publication Abstract to the page
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*[[Glutamate racemase 3D structures|Glutamate racemase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18614367 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_18614367}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2VVT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VVT OCA].
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==Reference==
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Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria., Geng B, Breault G, Comita-Prevoir J, Petrichko R, Eyermann C, Lundqvist T, Doig P, Gorseth E, Noonan B, Bioorg Med Chem Lett. 2008 Aug 1;18(15):4368-72. Epub 2008 Jun 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18614367 18614367]
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[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
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[[Category: Glutamate racemase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Breault G]]
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[[Category: Breault, G.]]
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[[Category: Comita-Prevoir J]]
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[[Category: Comita-Prevoir, J.]]
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[[Category: Doig P]]
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[[Category: Doig, P.]]
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[[Category: Eyermann C]]
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[[Category: Eyermann, C.]]
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[[Category: Geng B]]
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[[Category: Geng, B.]]
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[[Category: Gorseth E]]
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[[Category: Gorseth, E.]]
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[[Category: Lundqvist T]]
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[[Category: Lundqvist, T.]]
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[[Category: Noonan B]]
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[[Category: Noonan, B.]]
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[[Category: Petrichko R]]
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[[Category: Petrichko, R.]]
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[[Category: Benzyl purine]]
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[[Category: Cell shape]]
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[[Category: Cell wall biogenesis/degradation]]
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[[Category: Glutamate racemase]]
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[[Category: Isomerase]]
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[[Category: Muri inhibitor]]
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[[Category: Peptidoglycan synthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 6 09:49:51 2008''
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Current revision

Glutamate Racemase (MurI) from E. faecalis in complex with a 9-Benzyl Purine inhibitor

PDB ID 2vvt

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