3dy8

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(New page: '''Unreleased structure''' The entry 3dy8 is ON HOLD Authors: Liu, S., Mansour,M.N., Dillman, K., Perez, J., Danley, D., Menniti, F. Description: Human Phosphodiesterase 9 in complex w...)
Current revision (09:43, 21 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3dy8 is ON HOLD
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==Human Phosphodiesterase 9 in complex with product 5'-GMP (E+P complex)==
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<StructureSection load='3dy8' size='340' side='right'caption='[[3dy8]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3dy8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DY8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IBM:3-ISOBUTYL-1-METHYLXANTHINE'>IBM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dy8 OCA], [https://pdbe.org/3dy8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dy8 RCSB], [https://www.ebi.ac.uk/pdbsum/3dy8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dy8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/3dy8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dy8 ConSurf].
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<div style="clear:both"></div>
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Authors: Liu, S., Mansour,M.N., Dillman, K., Perez, J., Danley, D., Menniti, F.
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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Description: Human Phosphodiesterase 9 in complex with product 5'-GMP (E+P complex)
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== References ==
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<references/>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 6 12:31:53 2008''
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Danley D]]
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[[Category: Dillman K]]
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[[Category: Liu S]]
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[[Category: Mansour MN]]
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[[Category: Menniti F]]
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[[Category: Perez J]]

Current revision

Human Phosphodiesterase 9 in complex with product 5'-GMP (E+P complex)

PDB ID 3dy8

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