3cxl

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{{Seed}}
 
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[[Image:3cxl.jpg|left|200px]]
 
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==Crystal structure of human chimerin 1 (CHN1)==
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The line below this paragraph, containing "STRUCTURE_3cxl", creates the "Structure Box" on the page.
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<StructureSection load='3cxl' size='340' side='right'caption='[[3cxl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cxl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CXL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3cxl| PDB=3cxl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxl OCA], [https://pdbe.org/3cxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cxl RCSB], [https://www.ebi.ac.uk/pdbsum/3cxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cxl ProSAT]</span></td></tr>
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</table>
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===Crystal structure of human chimerin 1 (CHN1)===
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== Disease ==
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[https://www.uniprot.org/uniprot/CHIN_HUMAN CHIN_HUMAN] Defects in CHN1 are the cause of Duane retraction syndrome type 2 (DURS2) [MIM:[https://omim.org/entry/604356 604356]. Duane retraction syndrome is a congenital eye movement disorder characterized by a failure of cranial nerve VI (the abducens nerve) to develop normally, resulting in restriction or absence of abduction, adduction, or both, and narrowing of the palpebral fissure and retraction of the globe on attempted adduction. Undiagnosed in children, it can lead to amblyopia, a permanent uncorrectable loss of vision.
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== Function ==
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==About this Structure==
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[https://www.uniprot.org/uniprot/CHIN_HUMAN CHIN_HUMAN] GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
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3CXL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXL OCA].
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cxl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cxl ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Buck, M.]]
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[[Category: Buck M]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: MacKenzie, F.]]
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[[Category: MacKenzie F]]
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[[Category: Park, H.]]
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[[Category: Park H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Shen L]]
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[[Category: Shen, L.]]
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[[Category: Tempel W]]
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[[Category: Tempel, W.]]
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[[Category: Tong Y]]
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[[Category: Tong, Y.]]
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[[Category: Wilkstrom M]]
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[[Category: Wilkstrom, M.]]
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[[Category: Alternative splicing]]
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[[Category: C1]]
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[[Category: Gtpase activation]]
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[[Category: Metal-binding]]
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[[Category: Phorbol-ester binding]]
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[[Category: Rho-gap]]
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[[Category: Sgc]]
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[[Category: Sh2]]
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[[Category: Sh2 domain]]
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[[Category: Signaling protein]]
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[[Category: Structural genomics consortium]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 6 13:00:47 2008''
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Current revision

Crystal structure of human chimerin 1 (CHN1)

PDB ID 3cxl

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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