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3d32

From Proteopedia

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Complex of GABA(A) receptor-associated protein (GABARAP) with a synthetic peptide

Structural highlights

3d32 is a 4 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.3Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GBRAP_HUMAN May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity).^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein is a versatile adaptor protein playing an important role in intracellular vesicle trafficking, particularly in neuronal cells. We present the X-ray structure of the soluble form of human GABA(A) receptor-associated protein complexed with a high-affinity synthetic peptide at 1.3 A resolution. The data shed light on the probable binding modes of key interaction partners, including the GABA(A) receptor and the cysteine protease Atg4. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.

Ligand binding mode of GABAA receptor-associated protein.,Weiergraber OH, Stangler T, Thielmann Y, Mohrluder J, Wiesehan K, Willbold D J Mol Biol. 2008 Sep 19;381(5):1320-31. Epub 2008 Jul 7. PMID:18638487^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Lee JH, Rho SB, Chun T. GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47). Biotechnol Lett. 2005 May;27(9):623-8. PMID:15977068 doi:http://dx.doi.org/10.1007/s10529-005-3628-2
↑ Weiergraber OH, Stangler T, Thielmann Y, Mohrluder J, Wiesehan K, Willbold D. Ligand binding mode of GABAA receptor-associated protein. J Mol Biol. 2008 Sep 19;381(5):1320-31. Epub 2008 Jul 7. PMID:18638487 doi:10.1016/j.jmb.2008.06.086

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3d32"

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:3d32.jpg|left|200px]]
-<!--
+==Complex of GABA(A) receptor-associated protein (GABARAP) with a synthetic peptide==
-The line below this paragraph, containing "STRUCTURE_3d32", creates the "Structure Box" on the page.
+<StructureSection load='3d32' size='340' side='right'caption='[[3d32]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3d32]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D32 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-{{STRUCTURE_3d32|  PDB=3d32  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d32 OCA], [https://pdbe.org/3d32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d32 RCSB], [https://www.ebi.ac.uk/pdbsum/3d32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d32 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GBRAP_HUMAN GBRAP_HUMAN] May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity).<ref>PMID:15977068</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d3/3d32_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d32 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein is a versatile adaptor protein playing an important role in intracellular vesicle trafficking, particularly in neuronal cells. We present the X-ray structure of the soluble form of human GABA(A) receptor-associated protein complexed with a high-affinity synthetic peptide at 1.3 A resolution. The data shed light on the probable binding modes of key interaction partners, including the GABA(A) receptor and the cysteine protease Atg4. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.
-===Complex of GABA(A) receptor-associated protein (GABARAP) with a synthetic peptide===
+Ligand binding mode of GABAA receptor-associated protein.,Weiergraber OH, Stangler T, Thielmann Y, Mohrluder J, Wiesehan K, Willbold D J Mol Biol. 2008 Sep 19;381(5):1320-31. Epub 2008 Jul 7. PMID:18638487<ref>PMID:18638487</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3d32" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_18638487}}, adds the Publication Abstract to the page
+*[[GABA receptor-associated protein 3D structures|GABA receptor-associated protein 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 18638487 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_18638487}}
+__TOC__
+</StructureSection>
-==About this Structure==
-D32 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D32 OCA].
-==Reference==
-Ligand Binding Mode of GABA(A) Receptor-Associated Protein., Weiergraber OH, Stangler T, Thielmann Y, Mohrluder J, Wiesehan K, Willbold D, J Mol Biol. 2008 Jul 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18638487 18638487]
 [[Category: Homo sapiens]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Stangler, T.]]
+[[Category: Synthetic construct]]
-[[Category: Weiergraeber, O H.]]
+[[Category: Stangler T]]
-[[Category: Willbold, D.]]
+[[Category: Weiergraeber OH]]
-[[Category: Alpha-beta]]
+[[Category: Willbold D]]
-[[Category: Beta-grasp fold]]
-[[Category: Cytoplasm]]
-[[Category: Cytoskeleton]]
-[[Category: Golgi apparatus]]
-[[Category: Membrane]]
-[[Category: Microtubule]]
-[[Category: Transport]]
-[[Category: Transport protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug  6 13:01:48 2008''

3d32

From Proteopedia

Current revision

Complex of GABA(A) receptor-associated protein (GABARAP) with a synthetic peptide

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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