3dwd

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[[Image:3dwd.jpg|left|200px]]
 
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==Crystal structure of the ArfGAP domain of human ARFGAP1==
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The line below this paragraph, containing "STRUCTURE_3dwd", creates the "Structure Box" on the page.
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<StructureSection load='3dwd' size='340' side='right'caption='[[3dwd]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3dwd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DWD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3dwd| PDB=3dwd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dwd OCA], [https://pdbe.org/3dwd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dwd RCSB], [https://www.ebi.ac.uk/pdbsum/3dwd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dwd ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the ArfGAP domain of human ARFGAP1===
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== Function ==
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[https://www.uniprot.org/uniprot/ARFG1_HUMAN ARFG1_HUMAN] GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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3DWD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWD OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/3dwd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dwd ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Landry, R.]]
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[[Category: Landry R]]
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[[Category: Nedyalkova, L.]]
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[[Category: Nedyalkova L]]
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[[Category: Park, H.]]
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[[Category: Park H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Tempel W]]
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[[Category: Tempel, W.]]
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[[Category: Tong Y]]
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[[Category: Tong, Y.]]
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[[Category: Wilkstrom M]]
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[[Category: Wilkstrom, M.]]
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[[Category: Alternative splicing]]
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[[Category: Cytoplasm]]
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[[Category: Er-golgi transport]]
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[[Category: Gap]]
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[[Category: Golgi apparatus]]
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[[Category: Gtpase activating protein]]
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[[Category: Gtpase activation]]
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[[Category: Metal-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Protein transport]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 6 13:08:22 2008''
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Current revision

Crystal structure of the ArfGAP domain of human ARFGAP1

PDB ID 3dwd

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