2vim

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{{Seed}}
 
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[[Image:2vim.png|left|200px]]
 
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==X-ray structure of Fasciola hepatica thioredoxin==
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The line below this paragraph, containing "STRUCTURE_2vim", creates the "Structure Box" on the page.
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<StructureSection load='2vim' size='340' side='right'caption='[[2vim]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vim]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fasciola_hepatica Fasciola hepatica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VIM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.38&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vim OCA], [https://pdbe.org/2vim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vim RCSB], [https://www.ebi.ac.uk/pdbsum/2vim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vim ProSAT]</span></td></tr>
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{{STRUCTURE_2vim| PDB=2vim | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9U1G7_FASHE Q9U1G7_FASHE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vi/2vim_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vim ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Fasciola hepatica thioredoxin protein structure has been determined to 1.45A resolution. This is the first example of a single crystal structure to show the active site cysteine residues in both the reduced and disulfide oxidised form. Consistent with this observation the process of oxidation appears to require very little rearrangement of the surrounding protein structure. The F. hepatica thioredoxin structure has been compared to other thioredoxin protein structures already known and is found to be highly conserved. The F. hepatica protein is most similar to that of the thioredoxin from its human and animal hosts but it resembles other parasitic thioredoxins with regard to having no additional cysteine residues and is therefore not regulated by transient disulfide bond formation as proposed for thioredoxins from higher eukaryotic species.
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===X-RAY STRUCTURE OF FASCIOLA HEPATICA THIOREDOXIN===
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The Fasciola hepatica thioredoxin: High resolution structure reveals two oxidation states.,Line K, Isupov MN, Garcia-Rodriguez E, Maggioli G, Parra F, Littlechild JA Mol Biochem Parasitol. 2008 Sep;161(1):44-8. Epub 2008 Jun 21. PMID:18620002<ref>PMID:18620002</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2vim" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18620002}}, adds the Publication Abstract to the page
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*[[Art:Thioredoxin: A small protein with a radical role|Art:Thioredoxin: A small protein with a radical role]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18620002 is the PubMed ID number.
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
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-->
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== References ==
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{{ABSTRACT_PUBMED_18620002}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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2VIM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Fasciola_hepatica Fasciola hepatica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIM OCA].
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==Reference==
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The Fasciola hepatica thioredoxin: High resolution structure reveals two oxidation states., Line K, Isupov MN, Garcia-Rodriguez E, Maggioli G, Parra F, Littlechild JA, Mol Biochem Parasitol. 2008 Sep;161(1):44-8. Epub 2008 Jun 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18620002 18620002]
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Heterologous expression and functional characterization of thioredoxin from Fasciola hepatica., Salazar-Calderon M, Martin-Alonso JM, Ruiz de Eguino AD, Parra F, Parasitol Res. 2001 May;87(5):390-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11403382 11403382]
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[[Category: Fasciola hepatica]]
[[Category: Fasciola hepatica]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Garcia-Rodriguez, E.]]
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[[Category: Garcia-Rodriguez E]]
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[[Category: Isupov, M N.]]
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[[Category: Isupov MN]]
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[[Category: Line, K.]]
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[[Category: Line K]]
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[[Category: Littlechild, J A.]]
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[[Category: Littlechild JA]]
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[[Category: Maggioli, G.]]
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[[Category: Maggioli G]]
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[[Category: Parra, F.]]
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[[Category: Parra F]]
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[[Category: Oxidoreductase]]
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[[Category: Thioredoxin]]
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[[Category: Thioredoxin fold]]
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[[Category: Trx]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 13 13:42:06 2008''
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Current revision

X-ray structure of Fasciola hepatica thioredoxin

PDB ID 2vim

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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