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3e17
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3e17 is ON HOLD until Paper Publication Authors: Chen, H., Tong, S., Wu, J., Li, X., Zhu, Z., Niu, L., Teng, M. Description: Crystal structure of t...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the second PDZ domain from human Zona Occludens-2== | |
| + | <StructureSection load='3e17' size='340' side='right'caption='[[3e17]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3e17]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E17 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e17 OCA], [https://pdbe.org/3e17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e17 RCSB], [https://www.ebi.ac.uk/pdbsum/3e17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e17 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN] Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:[https://omim.org/entry/607748 607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.<ref>PMID:12704386</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN] Plays a role in tight junctions and adherens junctions. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/3e17_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e17 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Human zonula occludens 2 (ZO-2) protein is a multi-domain protein that consists of an SH3 domain, a GK domain and three copies of a PDZ domain with slight divergence. The three PDZ domains act as protein-recognition modules that may mediate protein assembly and subunit localization. The crystal structure of the second PDZ domain of ZO-2 (ZO-2 PDZ2) was determined by molecular replacement at 1.75 A resolution, revealing a dimer in the asymmetric unit. The dimer is stabilized by extensive symmetrical domain-swapping of the beta1 and beta2 strands. Structural comparison shows that the ZO-2 PDZ2 homodimer may have a similar ligand-binding pattern to the ZO-1 PDZ2-connexin 43 complex. | ||
| - | + | Structure of the second PDZ domain from human zonula occludens 2.,Chen H, Tong S, Li X, Wu J, Zhu Z, Niu L, Teng M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Apr 1;65(Pt, 4):327-30. Epub 2009 Mar 25. PMID:19342771<ref>PMID:19342771</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 3e17" style="background-color:#fffaf0;"></div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen H]] | ||
| + | [[Category: Niu LW]] | ||
| + | [[Category: Teng MK]] | ||
| + | [[Category: Tong SL]] | ||
Current revision
Crystal structure of the second PDZ domain from human Zona Occludens-2
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Categories: Homo sapiens | Large Structures | Chen H | Niu LW | Teng MK | Tong SL
