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1qy5

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(New page: 200px<br /><applet load="1qy5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qy5, resolution 1.75&Aring;" /> '''Crystal Structure of...)
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[[Image:1qy5.jpg|left|200px]]<br /><applet load="1qy5" size="450" color="white" frame="true" align="right" spinBox="true"
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#REDIRECT [[6d28]] This PDB entry is obsolete and replaced by 6d28
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caption="1qy5, resolution 1.75&Aring;" />
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'''Crystal Structure of the N-domain of the ER Hsp90 chaperone GRP94 in complex with the specific ligand NECA'''<br />
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==Overview==
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GRP94, the endoplasmic reticulum (ER) paralog of the chaperone Hsp90, plays an essential role in the structural maturation or secretion of a, subset of proteins destined for transport to the cell surface, such as the, Toll-like receptors 2 and 4, and IgG, respectively. GRP94 differs from, cytoplasmic Hsp90 by exhibiting very weak ATP binding and hydrolysis, activity. GRP94 also binds selectively to a series of substituted, adenosine analogs. The high resolution crystal structures at 1.75-2.1 A of, the N-terminal and adjacent charged domains of GRP94 in complex with, N-ethylcarboxamidoadenosine, radicicol, and 2-chlorodideoxyadenosine, reveals a structural mechanism for ligand discrimination among hsp90, family members. The structures also identify a putative subdomain that may, act as a ligand-responsive switch. The residues of the charged region fold, into a disordered loop whose termini are ordered and continue the twisted, beta sheet that forms the structural core of the N-domain. This, continuation of the beta sheet past the charged domain suggests a, structural basis for the association of the N-terminal and middle domains, of the full-length chaperone.
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==About this Structure==
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1QY5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris] with NEC and M2M as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QY5 OCA].
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==Reference==
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Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation., Soldano KL, Jivan A, Nicchitta CV, Gewirth DT, J Biol Chem. 2003 Nov 28;278(48):48330-8. Epub 2003 Sep 11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12970348 12970348]
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[[Category: Canis lupus familiaris]]
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[[Category: Single protein]]
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[[Category: Gewirth, D.T.]]
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[[Category: Jivan, A.]]
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[[Category: Nicchitta, C.V.]]
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[[Category: Soldano, K.L.]]
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[[Category: M2M]]
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[[Category: NEC]]
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[[Category: grp94]]
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[[Category: hsp90]]
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[[Category: neca]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:06:58 2007''
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Current revision

  1. REDIRECT 6d28 This PDB entry is obsolete and replaced by 6d28

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