1qy6

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(New page: 200px<br /><applet load="1qy6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qy6, resolution 1.9&Aring;" /> '''Structue of V8 Protea...)
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[[Image:1qy6.jpg|left|200px]]<br /><applet load="1qy6" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1qy6, resolution 1.9&Aring;" />
 
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'''Structue of V8 Protease from Staphylococcus aureus'''<br />
 
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==Overview==
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==Structue of V8 Protease from Staphylococcus aureus==
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V8 protease, an extracellular protease of Staphylococcus aureus, is, related to the pancreatic serine proteases. The enzyme cleaves peptide, bonds exclusively on the carbonyl side of aspartate and glutamate, residues. Unlike the pancreatic serine proteases, V8 protease possesses no, disulfide bridges. This is a major evolutionary difference, as all, pancreatic proteases have at least two disulfide bridges. The structure of, V8 protease shows structural similarity with several other serine, proteases, specifically the epidermolytic toxins A and B from S. aureus, and trypsin, in which the conformation of the active site is almost, identical. V8 protease is also unique in that the positively charged, N-terminus is involved in determining the substrate-specificity of the, enzyme.
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<StructureSection load='1qy6' size='340' side='right'caption='[[1qy6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1qy6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QY6 FirstGlance]. <br>
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1QY6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with K as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QY6 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qy6 OCA], [https://pdbe.org/1qy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qy6 RCSB], [https://www.ebi.ac.uk/pdbsum/1qy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qy6 ProSAT]</span></td></tr>
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The structure of a universally employed enzyme: V8 protease from Staphylococcus aureus., Prasad L, Leduc Y, Hayakawa K, Delbaere LT, Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):256-9. Epub 2004, Jan 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14747701 14747701]
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</table>
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[[Category: Glutamyl endopeptidase]]
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== Function ==
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[[Category: Single protein]]
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[https://www.uniprot.org/uniprot/SSPA_STAAM SSPA_STAAM] Preferentially cleaves peptide bonds on the carboxyl-terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases (By similarity).
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[[Category: Staphylococcus aureus]]
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== Evolutionary Conservation ==
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[[Category: Delbaere, L.T.J.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Hayakawa, K.]]
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Check<jmol>
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[[Category: Leduc, Y.]]
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<jmolCheckbox>
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[[Category: Prasad, L.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qy/1qy6_consurf.spt"</scriptWhenChecked>
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[[Category: K]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: serine protease]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:07:03 2007''
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qy6 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Staphylococcus aureus subsp. aureus Mu50]]
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[[Category: Delbaere LTJ]]
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[[Category: Hayakawa K]]
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[[Category: Leduc Y]]
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[[Category: Prasad L]]

Current revision

Structue of V8 Protease from Staphylococcus aureus

PDB ID 1qy6

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