2jww

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{{Seed}}
 
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[[Image:2jww.jpg|left|200px]]
 
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==Calcium-free rat alpha-parvalbumin==
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The line below this paragraph, containing "STRUCTURE_2jww", creates the "Structure Box" on the page.
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<StructureSection load='2jww' size='340' side='right'caption='[[2jww]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jww]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JWW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jww OCA], [https://pdbe.org/2jww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jww RCSB], [https://www.ebi.ac.uk/pdbsum/2jww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jww ProSAT]</span></td></tr>
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{{STRUCTURE_2jww| PDB=2jww | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRVA_RAT PRVA_RAT] In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/2jww_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jww ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mammals express two parvalbumins-an alpha isoform and a beta isoform. In rat, the alpha-parvalbumin (alpha-PV) exhibits superior divalent ion affinity. For example, the standard free energies for Ca2+ binding differ by 5.5 kcal/mol in 0.15 M KCl (pH 7.4). High-resolution structures of the Ca2+-bound proteins provide little insight into this disparity, prompting a structural analysis of the apo-proteins. A recent analysis of rat beta-PV suggested that Ca2+ removal provokes substantial conformational changes-reorientation of the C, D, and E helices; reorganization of the hydrophobic core; reduced interdomain contact; and remodeling of the AB domain. The energetic penalty attendant to reversing these changes, it was suggested, could contribute to the attenuated divalent ion-binding signature of that protein. That hypothesis is supported by data presented herein, describing the solution structure and peptide backbone dynamics of Ca2+-free rat alpha-PV. In marked contrast to rat beta-PV, the apo- and Ca2+-loaded forms of the rat alpha isoform are quite similar. Significant structural differences appear to be confined to the loop regions of the molecule. This finding implies that the alpha-PV isoform enjoys elevated divalent ion affinity because the metal ion-binding events do not require major structural rearrangement and the concomitant sacrifice of binding energy.
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===Calcium-free rat alpha-parvalbumin===
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Solution structure of Ca2+-free rat alpha-parvalbumin.,Henzl MT, Tanner JJ Protein Sci. 2008 Mar;17(3):431-8. Epub 2008 Jan 24. PMID:18218708<ref>PMID:18218708</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2jww" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18218708}}, adds the Publication Abstract to the page
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*[[Parvalbumin|Parvalbumin]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18218708 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18218708}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2JWW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWW OCA].
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==Reference==
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Solution structure of Ca2+-free rat alpha-parvalbumin., Henzl MT, Tanner JJ, Protein Sci. 2008 Mar;17(3):431-8. Epub 2008 Jan 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18218708 18218708]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Henzl MT]]
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[[Category: Henzl, M T.]]
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[[Category: Tanner JJ]]
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[[Category: Tanner, J J.]]
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[[Category: Acetylation]]
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[[Category: Alpha-parvalbumin]]
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[[Category: Calcium-free]]
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[[Category: Ef-hand protein]]
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[[Category: Metal binding protein]]
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[[Category: Muscle protein]]
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[[Category: Phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 13 13:58:52 2008''
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Current revision

Calcium-free rat alpha-parvalbumin

PDB ID 2jww

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