1r1f

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(New page: 200px<br /><applet load="1r1f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r1f" /> '''Solution Structure of the Cyclotide Palicour...)
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[[Image:1r1f.gif|left|200px]]<br /><applet load="1r1f" size="450" color="white" frame="true" align="right" spinBox="true"
 
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'''Solution Structure of the Cyclotide Palicourein: Implications for the development of pharmaceutical and agricultural applications'''<br />
 
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==Overview==
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==Solution Structure of the Cyclotide Palicourein: Implications for the development of pharmaceutical and agricultural applications==
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The cyclotides are a family of disulfide-rich proteins from plants. They, have the characteristic structural features of a circular protein backbone, and a knotted arrangement of disulfide bonds. Structural and biochemical, studies of the cyclotides suggest that their unique physiological, stability can be loaned to bioactive peptide fragments for pharmaceutical, and agricultural development. In particular, the cyclotides incorporate a, number of solvent-exposed loops that are potentially suitable for epitope, grafting applications. Here, we determine the structure of the largest, known cyclotide, palicourein, which has an atypical size and composition, within one of the surface-exposed loops. The structural data show that an, increase in size of a palicourein loop does not perturb the core fold, to, which the thermodynamic and chemical stability has been attributed. The, cyclotide core fold, thus, can in principle be used as a framework for the, development of useful pharmaceutical and agricultural bioactivities.
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<StructureSection load='1r1f' size='340' side='right'caption='[[1r1f]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1r1f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Palicourea_condensata Palicourea condensata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R1F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1f OCA], [https://pdbe.org/1r1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r1f RCSB], [https://www.ebi.ac.uk/pdbsum/1r1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r1f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PALIC_PALCO PALIC_PALCO] Probably participates in a plant defense mechanism. Inhibits the cytopathic effects of the human immunodeficiency virus.<ref>PMID:11430013</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The cyclotides are a family of disulfide-rich proteins from plants. They have the characteristic structural features of a circular protein backbone and a knotted arrangement of disulfide bonds. Structural and biochemical studies of the cyclotides suggest that their unique physiological stability can be loaned to bioactive peptide fragments for pharmaceutical and agricultural development. In particular, the cyclotides incorporate a number of solvent-exposed loops that are potentially suitable for epitope grafting applications. Here, we determine the structure of the largest known cyclotide, palicourein, which has an atypical size and composition within one of the surface-exposed loops. The structural data show that an increase in size of a palicourein loop does not perturb the core fold, to which the thermodynamic and chemical stability has been attributed. The cyclotide core fold, thus, can in principle be used as a framework for the development of useful pharmaceutical and agricultural bioactivities.
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==About this Structure==
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Solution structure of the cyclotide palicourein: implications for the development of a pharmaceutical framework.,Barry DG, Daly NL, Bokesch HR, Gustafson KR, Craik DJ Structure. 2004 Jan;12(1):85-94. PMID:14725768<ref>PMID:14725768</ref>
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1R1F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Palicourea_condensata Palicourea condensata]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1R1F OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Solution structure of the cyclotide palicourein: implications for the development of a pharmaceutical framework., Barry DG, Daly NL, Bokesch HR, Gustafson KR, Craik DJ, Structure. 2004 Jan;12(1):85-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14725768 14725768]
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</div>
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<div class="pdbe-citations 1r1f" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Palicourea condensata]]
[[Category: Palicourea condensata]]
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[[Category: Single protein]]
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[[Category: Barry DG]]
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[[Category: Barry, D.G.]]
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[[Category: Bokesch HR]]
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[[Category: Bokesch, H.R.]]
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[[Category: Craik DJ]]
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[[Category: Craik, D.J.]]
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[[Category: Daly NL]]
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[[Category: Daly, N.L.]]
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[[Category: Gustafson KR]]
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[[Category: Gustafson, K.R.]]
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[[Category: cyclotide]]
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[[Category: palicourein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:11:51 2007''
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Current revision

Solution Structure of the Cyclotide Palicourein: Implications for the development of pharmaceutical and agricultural applications

PDB ID 1r1f

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