3dkn

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{{Seed}}
 
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[[Image:3dkn.jpg|left|200px]]
 
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==Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum==
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The line below this paragraph, containing "STRUCTURE_3dkn", creates the "Structure Box" on the page.
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<SX load='3dkn' size='340' side='right' viewer='molstar' caption='[[3dkn]], [[Resolution|resolution]] 8.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DKN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkn OCA], [https://pdbe.org/3dkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dkn RCSB], [https://www.ebi.ac.uk/pdbsum/3dkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dkn ProSAT]</span></td></tr>
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{{STRUCTURE_3dkn| PDB=3dkn | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SECY_METJA SECY_METJA] The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/3dkn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dkn ConSurf].
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<div style="clear:both"></div>
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===Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum===
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==See Also==
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*[[Preprotein translocase 3D structures|Preprotein translocase 3D structures]]
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__TOC__
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</SX>
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The line below this paragraph, {{ABSTRACT_PUBMED_18611385}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18611385 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18611385}}
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==About this Structure==
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3DKN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA].
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==Reference==
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Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome., Menetret JF, Hegde RS, Aguiar M, Gygi SP, Park E, Rapoport TA, Akey CW, Structure. 2008 Jul;16(7):1126-37. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18611385 18611385]
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[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Akey, C.]]
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[[Category: Akey C]]
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[[Category: Menetret, J F.]]
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[[Category: Menetret J-F]]
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[[Category: Co-translational translocation]]
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[[Category: Cryo-electron microscopy]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Protein transport/rna complex]]
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[[Category: Ribosome-channel complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 20 12:07:16 2008''
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Current revision

Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum

3dkn, resolution 8.70Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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