3e68

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(New page: '''Unreleased structure''' The entry 3e68 is ON HOLD Authors: Garcin, E.D., Arvai, A.S., Rosenfeld, R.J., Kroeger, M.D., Crane, B.R., Andersson, G., Andrews, G., Hamley, P.J., Mallinder...)
Current revision (09:44, 21 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3e68 is ON HOLD
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==Structure of murine INOS oxygenase domain with inhibitor AR-C130232==
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<StructureSection load='3e68' size='340' side='right'caption='[[3e68]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3e68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E68 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AT6:N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE'>AT6</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e68 OCA], [https://pdbe.org/3e68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e68 RCSB], [https://www.ebi.ac.uk/pdbsum/3e68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e68 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/3e68_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e68 ConSurf].
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<div style="clear:both"></div>
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Authors: Garcin, E.D., Arvai, A.S., Rosenfeld, R.J., Kroeger, M.D., Crane, B.R., Andersson, G., Andrews, G., Hamley, P.J., Mallinder, P.R., Nicholls, D.J., St-Gallay, S.A., Tinker, A.C., Gensmantel, N.P., Mete, A., Cheshire, D.R., Connolly, S., Stueh, D.J., Aberg,
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==See Also==
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*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
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Description: Structure of murine INOS oxygenase domain with inhibitor AR-C130232
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== References ==
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<references/>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 27 11:00:42 2008''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Aberg A]]
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[[Category: Andersson G]]
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[[Category: Andrews G]]
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[[Category: Arvai AS]]
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[[Category: Cheshire DR]]
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[[Category: Connolly S]]
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[[Category: Crane BR]]
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[[Category: Garcin ED]]
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[[Category: Gensmantel NP]]
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[[Category: Getzoff ED]]
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[[Category: Hamley PJ]]
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[[Category: Kroeger MD]]
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[[Category: Mallinder PR]]
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[[Category: Mete A]]
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[[Category: Nicholls DJ]]
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[[Category: Rosenfeld RJ]]
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[[Category: St-Gallay SA]]
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[[Category: Stueh DJ]]
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[[Category: Tainer JA]]
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[[Category: Tinker AC]]
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[[Category: Wallace AV]]

Current revision

Structure of murine INOS oxygenase domain with inhibitor AR-C130232

PDB ID 3e68

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