3dzq

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{{Seed}}
 
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[[Image:3dzq.jpg|left|200px]]
 
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==Human EphA3 kinase domain in complex with inhibitor AWL-II-38.3==
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The line below this paragraph, containing "STRUCTURE_3dzq", creates the "Structure Box" on the page.
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<StructureSection load='3dzq' size='340' side='right'caption='[[3dzq]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3dzq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DZQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IFC:N-[2-METHYL-5-({[3-(4-METHYL-1H-IMIDAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL]CARBONYL}AMINO)PHENYL]ISOXAZOLE-5-CARBOXAMIDE'>IFC</scene></td></tr>
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{{STRUCTURE_3dzq| PDB=3dzq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dzq OCA], [https://pdbe.org/3dzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dzq RCSB], [https://www.ebi.ac.uk/pdbsum/3dzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dzq ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/EPHA3_HUMAN EPHA3_HUMAN] Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:[https://omim.org/entry/114500 114500].
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== Function ==
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[https://www.uniprot.org/uniprot/EPHA3_HUMAN EPHA3_HUMAN] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.<ref>PMID:11870224</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dz/3dzq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dzq ConSurf].
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<div style="clear:both"></div>
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===Human EphA3 kinase domain in complex with inhibitor AWL-II-38.3===
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==See Also==
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*[[Ephrin|Ephrin]]
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*[[Ephrin receptor 3D structures|Ephrin receptor 3D structures]]
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==About this Structure==
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== References ==
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3DZQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DZQ OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bochkarev A]]
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[[Category: Bochkarev, A.]]
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[[Category: Bountra C]]
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[[Category: Bountra, C.]]
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[[Category: Dhe-Paganon S]]
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[[Category: Dhe-Paganon, S.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Gray N]]
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[[Category: Gray, N.]]
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[[Category: Mackenzie F]]
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[[Category: Mackenzie, F.]]
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[[Category: Mansoor W]]
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[[Category: Mansoor, W.]]
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[[Category: Syeda F]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Walker JR]]
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[[Category: Syeda, F.]]
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[[Category: Weigelt J]]
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[[Category: Walker, J R.]]
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[[Category: Weigelt, J.]]
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[[Category: Atp-binding]]
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[[Category: Inhibitor-complex]]
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[[Category: Membrane]]
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[[Category: Nucleotide binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Phosphorylation]]
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[[Category: Receptor tyrosine kinase]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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[[Category: Transmembrane]]
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[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 27 11:35:13 2008''
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Current revision

Human EphA3 kinase domain in complex with inhibitor AWL-II-38.3

PDB ID 3dzq

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