2jkc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: {{Seed}} 200px <!-- The line below this paragraph, containing "STRUCTURE_2jkc", creates the "Structure Box" on the page. You may change the PDB parameter (which se...)
Current revision (14:52, 13 December 2023) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2jkc.jpg|left|200px]]
 
-
<!--
+
==Crystal Structure of E346D of Tryptophan 7-Halogenase (PrnA)==
-
The line below this paragraph, containing "STRUCTURE_2jkc", creates the "Structure Box" on the page.
+
<StructureSection load='2jkc' size='340' side='right'caption='[[2jkc]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2jkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JKC FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
-
{{STRUCTURE_2jkc| PDB=2jkc | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jkc OCA], [https://pdbe.org/2jkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jkc RCSB], [https://www.ebi.ac.uk/pdbsum/2jkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jkc ProSAT]</span></td></tr>
-
 
+
</table>
-
===CRYSTAL STRUCTURE OF E346D OF TRYPTOPHAN 7-HALOGENASE (PRNA)===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/PRNA_PSEFL PRNA_PSEFL] Involved in the biosynthesis of the antifungal antibiotic pyrrolnitrin. Catalyze the chlorination of tryptophan (Trp) at C7 position to yield 7-chloro-L-tryptophan (7-CLT). The reaction between FADH2, Cl-, and O2 generates the powerful oxidant HOCl, which is presumed to carry out the chlorination reaction. The reaction of HOCl with the active site Lys-79 generates a lysine chloramine, which plays a key role in directing regiospecific chlorination of substrate in this important class of biosynthetic enzymes. It is also able to use bromide ions to generate monobrominated Trp.<ref>PMID:10941070</ref> <ref>PMID:9172332</ref> <ref>PMID:9537395</ref>
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_16195462}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 16195462 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/2jkc_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_16195462}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
2JKC is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKC OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jkc ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
== References ==
-
Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination., Dong C, Flecks S, Unversucht S, Haupt C, van Pee KH, Naismith JH, Science. 2005 Sep 30;309(5744):2216-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16195462 16195462]
+
<references/>
-
[[Category: Single protein]]
+
__TOC__
-
[[Category: Naismith, J H.]]
+
</StructureSection>
-
[[Category: Zhu, X.]]
+
[[Category: Large Structures]]
-
[[Category: Enzymatic halogenation]]
+
[[Category: Pseudomonas fluorescens]]
-
[[Category: Flavin-dependent reaction mechanism]]
+
[[Category: Naismith JH]]
-
[[Category: Oxidoreductase]]
+
[[Category: Zhu X]]
-
[[Category: Tryptophan halogenase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 3 11:23:38 2008''
+

Current revision

Crystal Structure of E346D of Tryptophan 7-Halogenase (PrnA)

PDB ID 2jkc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jkc"
Personal tools