2qx9

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{{Seed}}
 
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[[Image:2qx9.jpg|left|200px]]
 
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==Crystal Structure of Quinone Reductase II==
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The line below this paragraph, containing "STRUCTURE_2qx9", creates the "Structure Box" on the page.
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<StructureSection load='2qx9' size='340' side='right'caption='[[2qx9]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2qx9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QX9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QX9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ML2:N-[2-(2-IODO-5-METHOXY-1H-INDOL-3-YL)ETHYL]ACETAMIDE'>ML2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2qx9| PDB=2qx9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qx9 OCA], [https://pdbe.org/2qx9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qx9 RCSB], [https://www.ebi.ac.uk/pdbsum/2qx9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qx9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qx/2qx9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qx9 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Quinone Reductase II===
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==See Also==
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*[[Quinone reductase 3D structures|Quinone reductase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18254726 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18254726}}
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==About this Structure==
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2QX9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QX9 OCA].
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==Reference==
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Kinetic, thermodynamic, and X-ray structural insights into the interaction of melatonin and analogs with quinone reductase 2., Calamini B, Santarsiero BD, Boutin JA, Mesecar AD, Biochem J. 2008 Feb 7;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18254726 18254726]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Boutin, J A.]]
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[[Category: Boutin JA]]
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[[Category: Calamini, B.]]
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[[Category: Calamini B]]
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[[Category: Mesecar, A D.]]
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[[Category: Mesecar AD]]
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[[Category: Santarsiero, B D.]]
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[[Category: Santarsiero BD]]
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[[Category: Cytoplasm]]
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[[Category: Fad]]
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[[Category: Flavoprotein]]
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[[Category: Metal-binding]]
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[[Category: Oxidoreductase]]
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[[Category: Polymorphism]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 3 13:03:03 2008''
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Current revision

Crystal Structure of Quinone Reductase II

PDB ID 2qx9

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