2vpa

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{{Seed}}
 
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[[Image:2vpa.png|left|200px]]
 
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==High resolution crystal structure of the antibiotic resistance protein NimA from Deinococcus radiodurans==
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The line below this paragraph, containing "STRUCTURE_2vpa", creates the "Structure Box" on the page.
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<StructureSection load='2vpa' size='340' side='right'caption='[[2vpa]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vpa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VPA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
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{{STRUCTURE_2vpa| PDB=2vpa | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpa OCA], [https://pdbe.org/2vpa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vpa RCSB], [https://www.ebi.ac.uk/pdbsum/2vpa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vpa ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9RW27_DEIRA Q9RW27_DEIRA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vpa_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vpa ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Many anaerobic human pathogenic bacteria are treated using 5-nitroimidazole-based (5-Ni) antibiotics, a class of inactive prodrugs that contain a nitro group. The nitro group must be activated in an anaerobic one-electron reduction and is therefore dependent on the redox system in the target cells. Antibiotic resistance towards 5-Ni drugs is found to be related to the nim genes (nimA, nimB, nimC, nimD, nimE and nimF), which are proposed to encode a reductase that is responsible for converting the nitro group of the antibiotic into a nonbactericidal amine. A mechanism for the Nim enzyme has been proposed in which two-electron reduction of the nitro group leads to the generation of nontoxic derivatives and confers resistance against these antibiotics. The cofactor was found to be important in the mechanism and was found to be covalently linked to the reactive His71. In this paper, the 1.2 A atomic resolution crystal structure of the 5-nitroimidazole antibiotic resistance protein NimA from Deinococcus radiodurans (DrNimA) is presented. A planar cofactor is clearly visible and well defined in the electron-density map adjacent to His71, the identification of the cofactor and its properties are discussed.
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===HIGH RESOLUTION CRYSTAL STRUCTURE OF THE ANTIBIOTIC RESISTANCE PROTEIN NIMA FROM DEINOCOCCUS RADIODURANS===
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High-resolution structure of the antibiotic resistance protein NimA from Deinococcus radiodurans.,Leiros HK, Tedesco C, McSweeney SM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt 6):442-7. doi:, 10.1107/S1744309108009901. Epub 2008 May 16. PMID:18540048<ref>PMID:18540048</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15492014}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2vpa" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15492014 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15492014}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2VPA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPA OCA].
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==Reference==
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Structural basis of 5-nitroimidazole antibiotic resistance: the crystal structure of NimA from Deinococcus radiodurans., Leiros HK, Kozielski-Stuhrmann S, Kapp U, Terradot L, Leonard GA, McSweeney SM, J Biol Chem. 2004 Dec 31;279(53):55840-9. Epub 2004 Oct 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15492014 15492014]
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[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Leiros, H K.S.]]
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[[Category: Leiros H-KS]]
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[[Category: Mcsweeney, S M.]]
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[[Category: McSweeney SM]]
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[[Category: Tedesco, C.]]
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[[Category: Tedesco C]]
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[[Category: Antibiotic resistance]]
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[[Category: Atomic resolution]]
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[[Category: Cofactor]]
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[[Category: Deinococcus radioduran]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 10 09:12:56 2008''
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Current revision

High resolution crystal structure of the antibiotic resistance protein NimA from Deinococcus radiodurans

PDB ID 2vpa

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