3eah
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3eah is ON HOLD Authors: Elsa D. Garcin, Andrew S. Arvai, Robin J. Rosenfeld, Matt D. Kroeger, Brian R. Crane, Gunilla Andersson, Glen Andrews, Pete...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of inhibited human eNOS oxygenase domain== | |
| + | <StructureSection load='3eah' size='340' side='right'caption='[[3eah]], [[Resolution|resolution]] 2.44Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3eah]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EAH FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.44Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=327:(3S,5E)-3-PROPYL-3,4-DIHYDROTHIENO[2,3-F][1,4]OXAZEPIN-5(2H)-IMINE'>327</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eah OCA], [https://pdbe.org/3eah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eah RCSB], [https://www.ebi.ac.uk/pdbsum/3eah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eah ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NOS3_HUMAN NOS3_HUMAN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.<ref>PMID:17264164</ref> Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.<ref>PMID:17264164</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eah_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eah ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Aberg A]] | ||
| + | [[Category: Andersson G]] | ||
| + | [[Category: Andrews G]] | ||
| + | [[Category: Arvai AS]] | ||
| + | [[Category: Cheshire DR]] | ||
| + | [[Category: Connolly S]] | ||
| + | [[Category: Crane BR]] | ||
| + | [[Category: Garcin ED]] | ||
| + | [[Category: Gensmantel NP]] | ||
| + | [[Category: Getzoff ED]] | ||
| + | [[Category: Hamley PJ]] | ||
| + | [[Category: Kroeger MD]] | ||
| + | [[Category: Mallinder PR]] | ||
| + | [[Category: Mete A]] | ||
| + | [[Category: Nicholls DJ]] | ||
| + | [[Category: Rosenfeld RJ]] | ||
| + | [[Category: St-Gallay SA]] | ||
| + | [[Category: Stuehr DJ]] | ||
| + | [[Category: Tainer JA]] | ||
| + | [[Category: Tinker AC]] | ||
| + | [[Category: Wallace AV]] | ||
Current revision
Structure of inhibited human eNOS oxygenase domain
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Categories: Homo sapiens | Large Structures | Aberg A | Andersson G | Andrews G | Arvai AS | Cheshire DR | Connolly S | Crane BR | Garcin ED | Gensmantel NP | Getzoff ED | Hamley PJ | Kroeger MD | Mallinder PR | Mete A | Nicholls DJ | Rosenfeld RJ | St-Gallay SA | Stuehr DJ | Tainer JA | Tinker AC | Wallace AV
