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1pl1

From Proteopedia

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{{Seed}}
 
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[[Image:1pl1.png|left|200px]]
 
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==Crystal structure of human glutathione transferase (GST) A1-1 in complex with a decarboxy-glutathione==
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The line below this paragraph, containing "STRUCTURE_1pl1", creates the "Structure Box" on the page.
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<StructureSection load='1pl1' size='340' side='right'caption='[[1pl1]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pl1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PL1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABY:N-(4-AMINOBUTANOYL)-S-(4-METHOXYBENZYL)-L-CYSTEINYLGLYCINE'>ABY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
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{{STRUCTURE_1pl1| PDB=1pl1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl1 OCA], [https://pdbe.org/1pl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pl1 RCSB], [https://www.ebi.ac.uk/pdbsum/1pl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pl1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GSTA1_HUMAN GSTA1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:20606271</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/1pl1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pl1 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human glutathione transferase (GST) A1-1 in complex with a decarboxy-glutathione===
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_16421451}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16421451 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_16421451}}
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==About this Structure==
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1PL1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL1 OCA].
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==Reference==
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New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix., Grahn E, Novotny M, Jakobsson E, Gustafsson A, Grehn L, Olin B, Madsen D, Wahlberg M, Mannervik B, Kleywegt GJ, Acta Crystallogr D Biol Crystallogr. 2006 Feb;62(Pt 2):197-207. Epub 2006, Jan 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16421451 16421451]
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[[Category: Glutathione transferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Grahn, E.]]
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[[Category: Grahn E]]
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[[Category: Grehn, L.]]
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[[Category: Grehn L]]
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[[Category: Gustafsson, A.]]
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[[Category: Gustafsson A]]
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[[Category: Jakobsson, E.]]
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[[Category: Jakobsson E]]
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[[Category: Kleywegt, G J.]]
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[[Category: Kleywegt GJ]]
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[[Category: Madsen, D.]]
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[[Category: Madsen D]]
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[[Category: Mannervik, B.]]
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[[Category: Mannervik B]]
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[[Category: Olin, B.]]
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[[Category: Olin B]]
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[[Category: Wahlberg, M.]]
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[[Category: Wahlberg M]]
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[[Category: Domain1:alpha-beta]]
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[[Category: Domain2:alpha-helical]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 17 13:06:32 2008''
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Current revision

Crystal structure of human glutathione transferase (GST) A1-1 in complex with a decarboxy-glutathione

PDB ID 1pl1

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