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1rgs

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(New page: 200px<br /><applet load="1rgs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rgs, resolution 2.8&Aring;" /> '''REGULATORY SUBUNIT OF...)
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[[Image:1rgs.gif|left|200px]]<br /><applet load="1rgs" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1rgs, resolution 2.8&Aring;" />
 
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'''REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE'''<br />
 
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==Overview==
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==REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE==
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In the molecular scheme of living organisms, adenosine 3',5'-monophosphate, (cyclic AMP or cAMP) has been a universal second messenger. In eukaryotic, cells, the primary receptors for cAMP are the regulatory subunits of, cAMP-dependent protein kinase. The crystal structure of a 1-91 deletion, mutant of the type I alpha regulatory subunit was refined to 2.8 A, resolution. Each of the two tandem cAMP binding domains provides an, extensive network of hydrogen bonds that buries the cyclic phosphate and, the ribose between two beta strands that are linked by a short alpha, helix. Each adenine base stacks against an aromatic ring that lies outside, the beta barrel. This structure provides a molecular basis for, understanding how cAMP binds cooperatively to its receptor protein, thus, mediating activation of the kinase.
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<StructureSection load='1rgs' size='340' side='right'caption='[[1rgs]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1rgs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. The August 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''cAMP-dependent Protein Kinase (PKA)'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_8 10.2210/rcsb_pdb/mom_2012_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RGS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rgs OCA], [https://pdbe.org/1rgs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rgs RCSB], [https://www.ebi.ac.uk/pdbsum/1rgs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rgs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAP0_BOVIN KAP0_BOVIN] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rg/1rgs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rgs ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1RGS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with CMP as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RGS OCA].
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*[[CAMP-dependent protein kinase 3D structures|CAMP-dependent protein kinase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains., Su Y, Dostmann WR, Herberg FW, Durick K, Xuong NH, Ten Eyck L, Taylor SS, Varughese KI, Science. 1995 Aug 11;269(5225):807-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7638597 7638597]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Dostmann, W.R.G.]]
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[[Category: Dostmann WRG]]
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[[Category: Durick, K.]]
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[[Category: Durick K]]
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[[Category: Eyck, L.Ten.]]
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[[Category: Herberg FW]]
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[[Category: Herberg, F.W.]]
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[[Category: Su Y]]
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[[Category: Su, Y.]]
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[[Category: Taylor SS]]
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[[Category: Taylor, S.S.]]
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[[Category: Ten Eyck L]]
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[[Category: Varughese, K.I.]]
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[[Category: Varughese KI]]
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[[Category: Xuong, N.H.]]
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[[Category: Xuong N-H]]
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[[Category: CMP]]
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[[Category: kinase]]
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[[Category: regulatory subunit]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:35:12 2007''
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Current revision

REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE

PDB ID 1rgs

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