1rii
From Proteopedia
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(New page: 200px<br /><applet load="1rii" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rii, resolution 1.70Å" /> '''Crystal structure of...) |
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| - | [[Image:1rii.gif|left|200px]]<br /><applet load="1rii" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1rii, resolution 1.70Å" /> | ||
| - | '''Crystal structure of phosphoglycerate mutase from M. Tuberculosis'''<br /> | ||
| - | == | + | ==Crystal structure of phosphoglycerate mutase from M. Tuberculosis== |
| - | The single-crystal X-ray structure of phosphoglycerate mutase from | + | <StructureSection load='1rii' size='340' side='right'caption='[[1rii]], [[Resolution|resolution]] 1.70Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1rii]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RII FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rii OCA], [https://pdbe.org/1rii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rii RCSB], [https://www.ebi.ac.uk/pdbsum/1rii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rii ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GPMA_MYCTU GPMA_MYCTU] Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/1rii_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rii ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The single-crystal X-ray structure of phosphoglycerate mutase from Mycobacterium tuberculosis has been determined at a resolution of 1.70 angstroms. The C-terminal tail of each of the subunits is flexible and disordered; however, for one of the four chains (chain A) all but five residues of the chain could be modeled. Noteworthy features of the structure include the active site and a proline-rich segment in each monomer forming a short left-handed polyprolyl helix. These segments lie on the enzyme surface and could conceivably participate in protein-protein interactions. | ||
| - | + | The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase.,Muller P, Sawaya MR, Pashkov I, Chan S, Nguyen C, Wu Y, Perry LJ, Eisenberg D Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):309-15. Epub 2005, Feb 24. PMID:15735341<ref>PMID:15735341</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1rii" style="background-color:#fffaf0;"></div> | |
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| - | + | ==See Also== | |
| + | *[[Phosphoglycerate mutase 3D structures|Phosphoglycerate mutase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis]] | ||
| + | [[Category: Chan S]] | ||
| + | [[Category: Eisenberg D]] | ||
| + | [[Category: Mueller P]] | ||
| + | [[Category: Pashkova I]] | ||
| + | [[Category: Perry J]] | ||
| + | [[Category: Sawaya MR]] | ||
| + | [[Category: Wu Y]] | ||
Current revision
Crystal structure of phosphoglycerate mutase from M. Tuberculosis
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