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3c56

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{{Seed}}
 
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[[Image:3c56.png|left|200px]]
 
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==Class II fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with N-(3-Hydroxypropyl)-glycolohydroxamic acid bisphosphate, a competitive inhibitor==
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The line below this paragraph, containing "STRUCTURE_3c56", creates the "Structure Box" on the page.
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<StructureSection load='3c56' size='340' side='right'caption='[[3c56]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3c56]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C56 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PH4:3-{HYDROXY[(PHOSPHONOOXY)ACETYL]AMINO}PROPYL+DIHYDROGEN+PHOSPHATE'>PH4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3c56| PDB=3c56 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c56 OCA], [https://pdbe.org/3c56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c56 RCSB], [https://www.ebi.ac.uk/pdbsum/3c56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c56 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALF_HELPY ALF_HELPY] Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/3c56_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c56 ConSurf].
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<div style="clear:both"></div>
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===Class II fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with N-(3-Hydroxypropyl)-glycolohydroxamic acid bisphosphate, a competitive inhibitor===
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==See Also==
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*[[Aldolase 3D structures|Aldolase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_18688832}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18688832 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18688832}}
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==About this Structure==
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3C56 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C56 OCA].
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==Reference==
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Synthesis and Biochemical Evaluation of Selective Inhibitors of Class II Fructose Bisphosphate Aldolases: Towards New Synthetic Antibiotics., Fonvielle M, Coincon M, Daher R, Desbenoit N, Kosieradzka K, Barilone N, Gicquel B, Sygusch J, Jackson M, Therisod M, Chemistry. 2008 Aug 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18688832 18688832]
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[[Category: Fructose-bisphosphate aldolase]]
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[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: M., Coincon.]]
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[[Category: Coincon M]]
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[[Category: Potvin-Dulude, P.]]
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[[Category: Potvin-Dulude P]]
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[[Category: Sygusch,J.]]
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[[Category: Sygusch J]]
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[[Category: Aldolase]]
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[[Category: Class ii]]
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[[Category: Fbp]]
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[[Category: Glycolysis]]
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[[Category: Inhibitor]]
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[[Category: Lyase]]
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[[Category: Metal-binding]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 18 09:24:17 2008''
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Current revision

Class II fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with N-(3-Hydroxypropyl)-glycolohydroxamic acid bisphosphate, a competitive inhibitor

PDB ID 3c56

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