Serine protease

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(correct spelling mistakes)
Current revision (12:28, 3 September 2015) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
<applet load="1ppb" size="350" color="white" frame="true" align="left" spinBox="true"
+
<StructureSection load='1ppb' size='450' side='right' scene='' caption='Thrombin light chain (aqua) and heavy chain (red) complex with inhibitor (PDB code [[1ppb]])'>
-
caption="Human Thrombin with PPACK inhibitor" />
+
-
'''Serine proteases''', so called due to the presence of a serine residue in the active site, are a class of enzymes that catalyse the hydrolysis of peptide bonds in proteins.
+
'''Serine proteases''', or '''proteinases''', so called due to the presence of a serine residue in the active site, are a class of enzymes that catalyse the hydrolysis of peptide bonds in proteins.
==Thrombin==
==Thrombin==
Line 9: Line 8:
The B chain consists of <scene name='Serine_Protease/Domains/1'>two domains</scene>. As is true for all of the "trypsin-like" serine proteases, each of the two thrombin domains consists mainly of a 6-stranded, antiparallel beta barrel. The specificity pocket (here filled with the Lys sidechain of the PPACK inhibitor) is in one side of the throat of the domain 2beta barrel, and the activation site is close next to it.
The B chain consists of <scene name='Serine_Protease/Domains/1'>two domains</scene>. As is true for all of the "trypsin-like" serine proteases, each of the two thrombin domains consists mainly of a 6-stranded, antiparallel beta barrel. The specificity pocket (here filled with the Lys sidechain of the PPACK inhibitor) is in one side of the throat of the domain 2beta barrel, and the activation site is close next to it.
 +
==3D structures of thrombin==
 +
[[Thrombin]]
-
<applet load="2ptc" size="350" color="white" frame="true" align="right" spinBox="true"
+
THis is <scene name='Serine_Protease/Aapk/1'>our protein fro CHEM361</scene>.
-
caption="Trypsin BPT1 complex" />
+
-
==Trypsin-BPTI complex==
+
==Trypsin==
-
The trypsin backbone is shown in pink and the trypsin inhibitor, BPTI, in yellow (PDB code [[2ptc]]). The <scene name='Serine_Protease/Active_site/3'>active site</scene> residues [Ser195-His57-Asp102-Ser214] are shown in green, the disulfide bond between residues 14-38 is shown in yellow and the Lys 15 sidechain at the specificity site in pink.
+
 
 +
See [[Trypsin]]
 +
 
 +
 
 +
==Gilman suc-AAPK-trypsin==
 +
[[2agg]]
{{Clear}}
{{Clear}}

Current revision

Thrombin light chain (aqua) and heavy chain (red) complex with inhibitor (PDB code 1ppb)

Drag the structure with the mouse to rotate
Retrieved from "http://52.214.119.220/wiki/index.php/Serine_protease"
Personal tools