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2yxj

From Proteopedia

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{{Seed}}
 
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[[Image:2yxj.png|left|200px]]
 
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==Crystal structure of Bcl-xL in complex with ABT-737==
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The line below this paragraph, containing "STRUCTURE_2yxj", creates the "Structure Box" on the page.
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<StructureSection load='2yxj' size='340' side='right'caption='[[2yxj]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2yxj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YXJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=N3C:4-{4-[(4-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>N3C</scene></td></tr>
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{{STRUCTURE_2yxj| PDB=2yxj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxj OCA], [https://pdbe.org/2yxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yxj RCSB], [https://www.ebi.ac.uk/pdbsum/2yxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yxj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yx/2yxj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yxj ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of Bcl-xL in complex with ABT-737===
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2YXJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXJ OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family., Lee EF, Czabotar PE, Smith BJ, Deshayes K, Zobel K, Colman PM, Fairlie WD, Cell Death Differ. 2007 Sep;14(9):1711-3. Epub 2007 Jun 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17572662 17572662]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Colman, P M.]]
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[[Category: Colman PM]]
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[[Category: Czabotar, P E.]]
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[[Category: Czabotar PE]]
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[[Category: Deshayes, K.]]
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[[Category: Deshayes K]]
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[[Category: Fairlie, W D.]]
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[[Category: Fairlie WD]]
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[[Category: Lee, E F.]]
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[[Category: Lee EF]]
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[[Category: Smith, B J.]]
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[[Category: Smith BJ]]
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[[Category: Zobel, K.]]
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[[Category: Zobel K]]
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[[Category: Apoptosis]]
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[[Category: Cancer therapeutic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 24 09:01:04 2008''
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Current revision

Crystal structure of Bcl-xL in complex with ABT-737

PDB ID 2yxj

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