1rl6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1rl6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rl6, resolution 2.0&Aring;" /> '''RIBOSOMAL PROTEIN L6'...)
Current revision (23:49, 27 December 2023) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1rl6.gif|left|200px]]<br /><applet load="1rl6" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1rl6, resolution 2.0&Aring;" />
 
-
'''RIBOSOMAL PROTEIN L6'''<br />
 
-
==Overview==
+
==RIBOSOMAL PROTEIN L6==
-
In all cells, protein synthesis is coordinated by the ribosome, a large, ribonucleoprotein particle that is composed of &gt; 50 distinct protein, molecules and several large RNA molecules. Here we present the crystal, structure of ribosomal protein L6 from the thermophilic bacterium Bacillus, stearothermophilus solved at 2.6 A resolution. L6 contains two domains, with almost identical folds, implying that it was created by an ancient, gene duplication event. The surface of the molecule displays several, likely sites of interaction with other components of the ribosome. The RNA, binding sites appear to be localized in the C-terminal domain whereas the, N-terminal domain contains the potential sites for protein-protein, interactions. The domain structure is homologous with several other, ribosomal proteins and to a large family of eukaryotic RNA binding, proteins.
+
<StructureSection load='1rl6' size='340' side='right'caption='[[1rl6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1rl6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RL6 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rl6 OCA], [https://pdbe.org/1rl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rl6 RCSB], [https://www.ebi.ac.uk/pdbsum/1rl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rl6 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RL6_GEOSE RL6_GEOSE] It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity). This protein binds to the 23S rRNA, and is important in its secondary structure.[HAMAP-Rule:MF_01365]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rl/1rl6_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rl6 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
In all cells, protein synthesis is coordinated by the ribosome, a large ribonucleoprotein particle that is composed of &gt; 50 distinct protein molecules and several large RNA molecules. Here we present the crystal structure of ribosomal protein L6 from the thermophilic bacterium Bacillus stearothermophilus solved at 2.6 A resolution. L6 contains two domains with almost identical folds, implying that it was created by an ancient gene duplication event. The surface of the molecule displays several likely sites of interaction with other components of the ribosome. The RNA binding sites appear to be localized in the C-terminal domain whereas the N-terminal domain contains the potential sites for protein-protein interactions. The domain structure is homologous with several other ribosomal proteins and to a large family of eukaryotic RNA binding proteins.
-
==About this Structure==
+
Ribosomal protein L6: structural evidence of gene duplication from a primitive RNA binding protein.,Golden BL, Ramakrishnan V, White SW EMBO J. 1993 Dec 15;12(13):4901-8. PMID:8262035<ref>PMID:8262035</ref>
-
1RL6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RL6 OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
Ribosomal protein L6: structural evidence of gene duplication from a primitive RNA binding protein., Golden BL, Ramakrishnan V, White SW, EMBO J. 1993 Dec 15;12(13):4901-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8262035 8262035]
+
</div>
-
[[Category: Geobacillus stearothermophilus]]
+
<div class="pdbe-citations 1rl6" style="background-color:#fffaf0;"></div>
-
[[Category: Single protein]]
+
-
[[Category: Davies, C.]]
+
-
[[Category: Golden, B.L.]]
+
-
[[Category: Ramakrishnan, V.]]
+
-
[[Category: White, S.W.]]
+
-
[[Category: alpha/beta protein]]
+
-
[[Category: gentamicin resistance]]
+
-
[[Category: ribosomal protein]]
+
-
[[Category: rna-binding protein]]
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:40:50 2007''
+
==See Also==
 +
*[[Ribosomal protein L6|Ribosomal protein L6]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Geobacillus stearothermophilus]]
 +
[[Category: Large Structures]]
 +
[[Category: Davies C]]
 +
[[Category: Golden BL]]
 +
[[Category: Ramakrishnan V]]
 +
[[Category: White SW]]

Current revision

RIBOSOMAL PROTEIN L6

PDB ID 1rl6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rl6"
Personal tools