2znr

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{{Seed}}
 
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[[Image:2znr.png|left|200px]]
 
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==Crystal structure of the DUB domain of human AMSH-LP==
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The line below this paragraph, containing "STRUCTURE_2znr", creates the "Structure Box" on the page.
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<StructureSection load='2znr' size='340' side='right'caption='[[2znr]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2znr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZNR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2znr| PDB=2znr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2znr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2znr OCA], [https://pdbe.org/2znr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2znr RCSB], [https://www.ebi.ac.uk/pdbsum/2znr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2znr ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the DUB domain of human AMSH-LP===
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== Function ==
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[https://www.uniprot.org/uniprot/STALP_HUMAN STALP_HUMAN] Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.<ref>PMID:18758443</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_18758443}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18758443 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zn/2znr_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18758443}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2ZNR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZNR OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2znr ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains., Sato Y, Yoshikawa A, Yamagata A, Mimura H, Yamashita M, Ookata K, Nureki O, Iwai K, Komada M, Fukai S, Nature. 2008 Sep 18;455(7211):358-62. Epub 2008 Aug 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18758443 18758443]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ubiquitin thiolesterase]]
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[[Category: Azusa Y]]
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[[Category: Azusa, Y.]]
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[[Category: Fukai S]]
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[[Category: Fukai, S.]]
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[[Category: Iwai K]]
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[[Category: Iwai, K.]]
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[[Category: Komada M]]
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[[Category: Komada, M.]]
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[[Category: Mimura H]]
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[[Category: Mimura, H.]]
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[[Category: Nureki O]]
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[[Category: Nureki, O.]]
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[[Category: Ookata K]]
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[[Category: Ookata, K.]]
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[[Category: Sato Y]]
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[[Category: Sato, Y.]]
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[[Category: Wang X]]
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[[Category: Wang, X.]]
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[[Category: Yamagata A]]
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[[Category: Yamagata, A.]]
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[[Category: Yamashita M]]
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[[Category: Yamashita, M.]]
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[[Category: Alternative splicing]]
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[[Category: Hydrolase]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Metalloprotease]]
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[[Category: Protease]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 24 09:13:14 2008''
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Current revision

Crystal structure of the DUB domain of human AMSH-LP

PDB ID 2znr

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OCA

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