1rmt

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(New page: 200px<br /><applet load="1rmt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rmt, resolution 1.40&Aring;" /> '''Crystal structure of...)
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[[Image:1rmt.gif|left|200px]]<br /><applet load="1rmt" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1rmt, resolution 1.40&Aring;" />
 
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'''Crystal structure of AphA class B acid phosphatase/phosphotransferase complexed with adenosine.'''<br />
 
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==About this Structure==
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==Crystal structure of AphA class B acid phosphatase/phosphotransferase complexed with adenosine.==
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1RMT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with MG and ADN as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RMT OCA].
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<StructureSection load='1rmt' size='340' side='right'caption='[[1rmt]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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[[Category: Acid phosphatase]]
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== Structural highlights ==
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[[Category: Escherichia coli]]
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<table><tr><td colspan='2'>[[1rmt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RMT FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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[[Category: Benvenuti, M.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Calderone, V.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rmt OCA], [https://pdbe.org/1rmt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rmt RCSB], [https://www.ebi.ac.uk/pdbsum/1rmt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rmt ProSAT]</span></td></tr>
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[[Category: Forleo, C.]]
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</table>
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[[Category: Mangani, S.]]
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== Function ==
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[[Category: Rossolini, G.M.]]
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[https://www.uniprot.org/uniprot/APHA_ECOLI APHA_ECOLI] Dephosphorylates several organic phosphate monoesters including 3'- and 5'-nucleotides, 2'-deoxy-5'-nucleotides, pNPP, phenyl phosphate, glycerol 2-phosphate, ribose 5-phosphate, O-phospho-L-amino acids and phytic acid, showing the highest activity with aryl phosphoesters (pNPP, phenyl phosphate and O-phospho-L-tyrosine), and to a lesser extent with 3'- and 5'-nucleotides. No activity toward ATP, phosphodiesters, glycerol-1-phosphate, glucose 1-phosphate, glucose 6-phosphate, NADP, GTP or 3',5'-cAMP, ADP or ATP. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds. Capable of transferring phosphate from either pNPP or UMP to adenosine or uridine. Does not exhibit nucleotide phosphomutase activity.<ref>PMID:9011040</ref> <ref>PMID:16297670</ref>
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[[Category: Thaller, M.C.]]
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== Evolutionary Conservation ==
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[[Category: ADN]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: MG]]
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Check<jmol>
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[[Category: adenosine.]]
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<jmolCheckbox>
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[[Category: class b acid phosphatase]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rm/1rmt_consurf.spt"</scriptWhenChecked>
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[[Category: dddd acid phosphatase]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: metallo-enzyme]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rmt ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:43:13 2007''
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==See Also==
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*[[Acid phosphatase 3D structures|Acid phosphatase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Benvenuti M]]
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[[Category: Calderone V]]
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[[Category: Forleo C]]
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[[Category: Mangani S]]
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[[Category: Rossolini GM]]
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[[Category: Thaller MC]]

Current revision

Crystal structure of AphA class B acid phosphatase/phosphotransferase complexed with adenosine.

PDB ID 1rmt

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