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2yuk

From Proteopedia

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{{Seed}}
 
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[[Image:2yuk.png|left|200px]]
 
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<!--
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==Solution structure of the HMG box of human Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog==
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The line below this paragraph, containing "STRUCTURE_2yuk", creates the "Structure Box" on the page.
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<StructureSection load='2yuk' size='340' side='right'caption='[[2yuk]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2yuk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YUK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yuk OCA], [https://pdbe.org/2yuk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yuk RCSB], [https://www.ebi.ac.uk/pdbsum/2yuk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yuk ProSAT], [https://www.topsan.org/Proteins/RSGI/2yuk TOPSAN]</span></td></tr>
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{{STRUCTURE_2yuk| PDB=2yuk | SCENE= }}
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</table>
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== Function ==
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===Solution structure of the HMG box of human Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog===
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[https://www.uniprot.org/uniprot/KMT2C_HUMAN KMT2C_HUMAN] Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.<ref>PMID:17500065</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2YUK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YUK OCA].
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<jmolCheckbox>
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[[Category: Histone-lysine N-methyltransferase]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yu/2yuk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yuk ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Abe, H.]]
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[[Category: Abe H]]
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[[Category: Harada, T.]]
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[[Category: Harada T]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: Miyamoto, K.]]
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[[Category: Miyamoto K]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Tochio N]]
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[[Category: Tochio, N.]]
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[[Category: Watanabe S]]
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[[Category: Watanabe, S.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: H3 lysine-4 specific mll3]]
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[[Category: Histone-lysine n-methyltransferase]]
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[[Category: Homologous to alr protein]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Sep 28 15:02:20 2008''
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Current revision

Solution structure of the HMG box of human Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog

PDB ID 2yuk

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