2d8c

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{{Seed}}
 
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[[Image:2d8c.png|left|200px]]
 
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==Solution structure of the sam-domain of mouse phosphatidyl ceramidecholinephosphotransferase 1==
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The line below this paragraph, containing "STRUCTURE_2d8c", creates the "Structure Box" on the page.
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<StructureSection load='2d8c' size='340' side='right'caption='[[2d8c]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2d8c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D8C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d8c OCA], [https://pdbe.org/2d8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d8c RCSB], [https://www.ebi.ac.uk/pdbsum/2d8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d8c ProSAT], [https://www.topsan.org/Proteins/RSGI/2d8c TOPSAN]</span></td></tr>
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{{STRUCTURE_2d8c| PDB=2d8c | SCENE= }}
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</table>
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== Function ==
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===Solution structure of the sam-domain of mouse phosphatidyl ceramidecholinephosphotransferase 1===
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[https://www.uniprot.org/uniprot/SMS1_MOUSE SMS1_MOUSE] Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types (By similarity). Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.<ref>PMID:16879426</ref> <ref>PMID:22580896</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2D8C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8C OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d8/2d8c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d8c ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Goroncy AK]]
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[[Category: Goroncy, A K.]]
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[[Category: Inoue M]]
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[[Category: Inoue, M.]]
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[[Category: Kigawa T]]
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[[Category: Kigawa, T.]]
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[[Category: Kobayashi N]]
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[[Category: Kobayashi, N.]]
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[[Category: Koshiba S]]
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[[Category: Koshiba, S.]]
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[[Category: Tochio N]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Tomizawa T]]
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[[Category: Tochio, N.]]
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[[Category: Yokoyama S]]
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[[Category: Tomizawa, T.]]
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[[Category: Yokoyama, S.]]
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[[Category: Cell-free protein synthesis]]
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[[Category: Lipid metabolism]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Protein regulation]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Sep 28 17:38:19 2008''
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Current revision

Solution structure of the sam-domain of mouse phosphatidyl ceramidecholinephosphotransferase 1

PDB ID 2d8c

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