2d9s

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{{Seed}}
 
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[[Image:2d9s.png|left|200px]]
 
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==Solution structure of RSGI RUH-049, a UBA domain from mouse cDNA==
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The line below this paragraph, containing "STRUCTURE_2d9s", creates the "Structure Box" on the page.
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<StructureSection load='2d9s' size='340' side='right'caption='[[2d9s]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2d9s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D9S FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d9s OCA], [https://pdbe.org/2d9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d9s RCSB], [https://www.ebi.ac.uk/pdbsum/2d9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d9s ProSAT], [https://www.topsan.org/Proteins/RSGI/2d9s TOPSAN]</span></td></tr>
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{{STRUCTURE_2d9s| PDB=2d9s | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CBL_MOUSE CBL_MOUSE] Note=Can be converted to an oncogenic protein by deletions or mutations that disturb its ability to down-regulate RTKs.
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== Function ==
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[https://www.uniprot.org/uniprot/CBL_MOUSE CBL_MOUSE] Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The Tyr-737 phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function.<ref>PMID:9653117</ref> <ref>PMID:10393178</ref> <ref>PMID:12649282</ref> <ref>PMID:19265199</ref> <ref>PMID:20100865</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/2d9s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d9s ConSurf].
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<div style="clear:both"></div>
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===Solution structure of RSGI RUH-049, a UBA domain from mouse cDNA===
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2D9S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D9S OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Guntert P]]
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[[Category: Guntert, P.]]
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[[Category: Hamada T]]
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[[Category: Hamada, T.]]
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[[Category: Hirota H]]
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[[Category: Hirota, H.]]
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[[Category: Izumi K]]
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[[Category: Izumi, K.]]
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[[Category: Kigawa T]]
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[[Category: Kigawa, T.]]
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[[Category: Koshiba S]]
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[[Category: Koshiba, S.]]
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[[Category: Kurosaki C]]
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[[Category: Kurosaki, C.]]
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[[Category: Lin Y-J]]
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[[Category: Lin, Y J.]]
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[[Category: Yokoyama S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Yoshida M]]
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[[Category: Yokoyama, S.]]
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[[Category: Yoshida, M.]]
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[[Category: Dimer]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nmr]]
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[[Category: Nppsfa]]
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[[Category: Protein binding]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Uba domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Sep 28 18:09:27 2008''
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Current revision

Solution structure of RSGI RUH-049, a UBA domain from mouse cDNA

PDB ID 2d9s

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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