1wi4

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{{Seed}}
 
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[[Image:1wi4.png|left|200px]]
 
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==Solution structure of the PDZ domain of syntaxin binding protein 4==
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The line below this paragraph, containing "STRUCTURE_1wi4", creates the "Structure Box" on the page.
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<StructureSection load='1wi4' size='340' side='right'caption='[[1wi4]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wi4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WI4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi4 OCA], [https://pdbe.org/1wi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wi4 RCSB], [https://www.ebi.ac.uk/pdbsum/1wi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi4 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wi4 TOPSAN]</span></td></tr>
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{{STRUCTURE_1wi4| PDB=1wi4 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/STXB4_MOUSE STXB4_MOUSE] Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose.<ref>PMID:10394363</ref> <ref>PMID:12855681</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/1wi4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wi4 ConSurf].
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<div style="clear:both"></div>
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===Solution structure of the PDZ domain of syntaxin binding protein 4===
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==See Also==
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*[[Syntaxin-binding protein|Syntaxin-binding protein]]
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== References ==
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==About this Structure==
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<references/>
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1WI4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI4 OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Endo H]]
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[[Category: Endo, H.]]
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[[Category: Hayashi F]]
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[[Category: Hayashi, F.]]
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[[Category: Kigawa T]]
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[[Category: Kigawa, T.]]
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[[Category: Tomizawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Yokoyama S]]
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[[Category: Tomizawa, T.]]
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[[Category: Yoshida M]]
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[[Category: Yokoyama, S.]]
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[[Category: Yoshida, M.]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Stxbp4 protein]]
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[[Category: Synip]]
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[[Category: Syntaxin4-interacting protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Sep 28 21:06:03 2008''
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Current revision

Solution structure of the PDZ domain of syntaxin binding protein 4

PDB ID 1wi4

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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