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1s80

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(New page: 200px<br /><applet load="1s80" size="450" color="white" frame="true" align="right" spinBox="true" caption="1s80, resolution 2.70&Aring;" /> '''Structure of Serine ...)
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[[Image:1s80.gif|left|200px]]<br /><applet load="1s80" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1s80, resolution 2.70&Aring;" />
 
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'''Structure of Serine Acetyltranferase from Haemophilis influenzae Rd'''<br />
 
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==Overview==
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==Structure of Serine Acetyltransferase from Haemophilis influenzae Rd==
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The crystal structure of serine acetyltransferase (SAT) from Haemophilus, influenzae Rd determined at 2.7 A resolution is presented. SAT is a member, of a family of hexapeptide-containing transferases that contain, six-residue tandem repeats (LIV)-G-X(4) that have been shown to form, left-handed parallel beta-helices. In the current structure, each protomer, is comprised of two domains: an N-terminal alpha-helical domain and a, C-terminal left-handed parallel beta-helix domain. Although other members, of this protein family are known to form trimeric structures, SAT forms a, dimer of trimers in which the trimer interface is mediated through, interactions between both the beta-helix domains and N-terminal domains;, these trimers dimerize through contacts in the N-terminal domain. All, dimer-of-trimer interactions are mediated through amino acids within an, N-terminal extension common only to a subset of SATs, suggesting that, members of this subfamily may also adopt hexameric structures. Putative, active sites are formed by crevices between adjacent protomers in a, trimer. Thus, six independent active sites exist in the hexameric enzyme, complex.
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<StructureSection load='1s80' size='340' side='right'caption='[[1s80]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1s80]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S80 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s80 OCA], [https://pdbe.org/1s80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s80 RCSB], [https://www.ebi.ac.uk/pdbsum/1s80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s80 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1s80 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYSE_HAEIN CYSE_HAEIN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s8/1s80_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s80 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1S80 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Active as [http://en.wikipedia.org/wiki/Serine_O-acetyltransferase Serine O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.30 2.3.1.30] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1S80 OCA].
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*[[Serine acetyltransferase|Serine acetyltransferase]]
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__TOC__
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==Reference==
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</StructureSection>
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Structure of serine acetyltransferase from Haemophilus influenzae Rd., Gorman J, Shapiro L, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1600-5. Epub 2004, Aug 26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15333931 15333931]
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[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Serine O-acetyltransferase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Burley SK]]
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[[Category: Burley, S.K.]]
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[[Category: Gogos A]]
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[[Category: Gogos, A.]]
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[[Category: Gorman J]]
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[[Category: Gorman, J.]]
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[[Category: Shapiro L]]
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[[Category: NYSGXRC, New.York.Structural.GenomiX.Research.Consortium.]]
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[[Category: Shapiro, L.]]
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[[Category: new york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: psi]]
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[[Category: structural genomics; protein structure initiative; serine acetyltransferase; left-handed parallel beta-helix; nysgxrc]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:11:20 2007''
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Current revision

Structure of Serine Acetyltransferase from Haemophilis influenzae Rd

PDB ID 1s80

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