1wix
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:1wix.png|left|200px]] | ||
| - | + | ==The solution structure of RSGI RUH-026, conserved domain of HOOK1 protein from mouse== | |
| - | + | <StructureSection load='1wix' size='340' side='right'caption='[[1wix]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1wix]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WIX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wix OCA], [https://pdbe.org/1wix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wix RCSB], [https://www.ebi.ac.uk/pdbsum/1wix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wix ProSAT], [https://www.topsan.org/Proteins/RSGI/1wix TOPSAN]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Disease == | |
| - | + | [https://www.uniprot.org/uniprot/HOOK1_MOUSE HOOK1_MOUSE] Note=Defects in Hook1 are the cause of the azh (abnormal spermatozoon head shape) mutant phenotype, which induces spermatozoa with highly abnormal head morphology that differs drastically from the compact and hook-shaped head of the normal sperm, leading to a strong decrease of fertility. | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/HOOK1_MOUSE HOOK1_MOUSE] Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. | |
| - | == | + | == Evolutionary Conservation == |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/1wix_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wix ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | + | [[Category: Hayashi F]] | |
| - | [[Category: Hayashi | + | [[Category: Hirota H]] |
| - | [[Category: Hirota | + | [[Category: Ohashi W]] |
| - | [[Category: Ohashi | + | [[Category: Yamazaki T]] |
| - | + | [[Category: Yokoyama S]] | |
| - | [[Category: Yamazaki | + | |
| - | [[Category: Yokoyama | + | |
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Current revision
The solution structure of RSGI RUH-026, conserved domain of HOOK1 protein from mouse
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